Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825145 | 0.84 | EGLN2 (0.42) | POLBEGFRMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5937417 | 0.84 | EGFR (0.44) | EGFRMAPK14 | |
| SCHEMBL4707492 | 0.83 | SLC6A4 (0.48) | SLC6A4SLC6A3HPGDEGFRMAPT | |
| SCHEMBL5937251 | 0.82 | SLC6A4 (0.47) | SLC6A4SLC6A3HPGDSMN1; SMN2EGFR | |
| SCHEMBL792053 | 0.80 | SIRT2 (0.50) | HPGDTP53POLBSMN1; SMN2MAPT | |
| SCHEMBL792121 | 0.79 | ADRB2 (0.49) | SLC6A4SLC6A3HPGDTP53POLB | |
| SCHEMBL1521130 | 0.78 | MAP2K4 (0.46) | SLC6A4SLC6A3EGFRMAPTNPC1 | |
| SCHEMBL23484572 | 0.78 | SLC6A3 (0.54) | SLC6A4SLC6A3HPGDEGFRMAPT | |
| SCHEMBL2417490 | 0.77 | KDM4E (0.43) | POLBSMN1; SMN2EGFRMAPTLMNA | |
| SCHEMBL14686222 | 0.77 | EGFR (0.50) | SLC6A4SLC6A3POLBSMN1; SMN2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004007493-A1 | ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |