Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DDX3X | O00571 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6716867 | 0.84 | POLB (0.42) | POLBHPGDALDH1A1TSHRKMT2A | |
| SCHEMBL6723693 | 0.72 | KMT2A (0.43) | POLBHPGDALDH1A1KMT2ARAB9A | |
| SCHEMBL6824939 | 0.68 | POLB (0.46) | POLBHPGDALDH1A1TSHRKMT2A | |
| SCHEMBL7067161 | 0.66 | KMT2A (0.62) | POLBTSHRKMT2AMAPT | |
| SCHEMBL29521664 | 0.64 | POLB (0.75) | POLBHPGDALDH1A1TSHRKMT2A | |
| SCHEMBL81434 | 0.64 | POLB (0.75) | POLBHPGDALDH1A1TSHRKMT2A | |
| SCHEMBL8344357 | 0.63 | NPC1 (0.60) | POLBHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL8346804 | 0.63 | NPC1 (0.60) | POLBHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL5186841 | 0.63 | MDM4 (0.67) | POLBHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL194142 | 0.62 | ALDH1A1 (0.66) | POLBHPGDALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004022534-A1 | ARYLGLYCINE DERIVATIVES FOR USE AS GLYCINE TRANSPORT INHIBITORS | NPS ALLELIX CORP. (CA) | 2004-03-18 | — | — | WO | disclosed |