Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | NNMT | P40261 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10261196 | 0.88 | ALDH1A1 (0.47) | PARP1TDP1MAPTLCKALDH1A1 | |
| SCHEMBL13544664 | 0.88 | PARP1 (0.47) | PARP1TDP1SIRT3NNMTMAPT | |
| SCHEMBL13254936 | 0.88 | TDP1 (0.44) | TDP1SIRT3NNMTMAPTMAPK1 | |
| SCHEMBL2128609 | 0.84 | PARP1 (0.52) | PARP1TDP1SIRT3NNMTLCK | |
| SCHEMBL19993588 | 0.84 | PARP1 (0.44) | PARP1TDP1SIRT3NNMTMAPT | |
| SCHEMBL29503140 | 0.82 | PRSS1 (0.61) | PARP1TDP1MAPTLCKALDH1A1 | |
| SCHEMBL1002832 | 0.82 | PRSS1 (0.61) | PARP1TDP1MAPTLCKALDH1A1 | |
| SCHEMBL7481641 | 0.81 | TDP1 (0.52) | PARP1TDP1MAPTALDH1A1KDM4E | |
| SCHEMBL7083041 | 0.81 | NNMT (0.50) | PARP1TDP1SIRT3NNMTMAPT | |
| SCHEMBL1003845 | 0.80 | MEN1 (0.53) | PARP1TDP1SIRT3MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288552-B2 | Dihydropyridone amidesas P2X7 modulators | ROCHE PALO ALTO LLC (US) | 2012-10-16 | — | — | US | claimed |
| US-8835673-B2 | Process for preparing isocyanates | BASF SE (DE) | 2014-09-16 | — | — | US | disclosed |
| WO-2013142266-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | SERAGON PHARMACEUTICALS, INC. (US) | 2013-09-26 | — | — | WO | disclosed |
| US-20120253063-A1 | PROCESS FOR PREPARING ISOCYANATES | BASF SE (DE) | 2012-10-04 | — | — | US | disclosed |
| US-6781010-B1 | OBTAINED DIRECTLY BY THE SYNTHESIS AND THERMOLYSIS OF THE REACTION PRODUCT OF THE CORRESPONDING FORMAMIDE AND A DIORGANOCARBONATE | LYONDELL CHEMICAL COMPANY | 2004-08-24 | — | — | US | disclosed |
| WO-2002024634-A2 | NON-PHOSGENE ROUTE TO THE MANUFACTURE OF ORGANIC ISOCYANATES | ARCO CHEMICAL TECHNOLOGY, L.P. (US) | 2002-03-28 | — | — | WO | disclosed |
| US-5686645-A | REACTION WITH ALCOHOL TO FORM CARBAMATE, TRANSITION METAL CATALYST | ARCO CHEMICAL TECHNOLOGY, L.P. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5155267-A | Forming unsymmetric carbamates and ureas; reacting primary formamide with dialkyl amine or alcohol | ARCO CHEMICAL TECHNOLOGY, L.P. (US) | 1992-10-13 | — | — | US | disclosed |
| US-4455309-A | MICROBIOCIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1984-06-19 | — | — | US | disclosed |
| US-4259258-A | Preparation of bis-n-chloramides of cycloaliphatic carboxylic acids | AKZONA INCORPORATED (US) | 1981-03-31 | — | — | US | disclosed |