Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17141437 | 0.84 | POLB (0.43) | ALDH1A1LMNARAB9AL3MBTL1POLB | |
| SCHEMBL1750237 | 0.84 | ALDH1A1 (0.46) | CASP1ALDH1A1LMNARAB9AL3MBTL1 | |
| SCHEMBL15633425 | 0.82 | KDM4E (0.46) | ALDH1A1LMNARAB9AL3MBTL1POLB | |
| SCHEMBL24158869 | 0.80 | NNMT (0.45) | CASP1ALDH1A1NNMTPOLBROCK2 | |
| SCHEMBL1751822 | 0.79 | HMGCR (0.44) | ALDH1A1LMNARAB9AL3MBTL1POLB | |
| SCHEMBL25228251 | 0.78 | ALDH1A1 (0.39) | ALDH1A1LMNARAB9AL3MBTL1POLB | |
| SCHEMBL669037 | 0.75 | CASP1 (0.56) | CASP1ALDH1A1LMNARAB9AL3MBTL1 | |
| SCHEMBL12611466 | 0.74 | NNMT (0.46) | CASP1ALDH1A1LMNARAB9ANNMT | |
| SCHEMBL24342278 | 0.73 | IKBKB (0.42) | CASP1ALDH1A1LMNANNMTSYK | |
| SCHEMBL16853382 | 0.73 | SYK (0.41) | CASP1ALDH1A1LMNARAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108707-A1 | PYRIDAZINIL QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2004-12-16 | — | — | WO | disclosed |