Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.47 |
| ▸ | HEXA | P06865 | 1/20 | 0.45 |
| ▸ | HEXB | P07686 | 1/20 | 0.45 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243063 | 0.82 | KIF11 (0.47) | KIF11HEXAHEXBNOS3NOS2 | |
| SCHEMBL29888283 | 0.75 | MKNK1 (0.54) | KIF11KDRTLR7MAP4K4MKNK1 | |
| SCHEMBL30544068 | 0.74 | KIF11 (0.50) | KIF11HEXAHEXBNOS3NOS2 | |
| SCHEMBL27856886 | 0.74 | KIF11 (0.50) | KIF11HEXAHEXBNOS3NOS2 | |
| SCHEMBL6826885 | 0.74 | NOS3 (0.46) | KIF11HEXAHEXBUSP7NOS3 | |
| SCHEMBL25250732 | 0.71 | KIF11 (0.47) | KIF11HEXAHEXBUSP7CCNB2 | |
| SCHEMBL29013658 | 0.70 | KIF11 (0.60) | KIF11HEXAHEXBMKNK1MKNK2 | |
| SCHEMBL29360194 | 0.69 | GSK3B (0.46) | HEXAHEXBUSP7NOS3NOS2 | |
| SCHEMBL4647645 | 0.69 | GSK3B (0.46) | HEXAHEXBUSP7NOS3NOS2 | |
| SCHEMBL14553725 | 0.69 | TOP2A (0.60) | KIF11CCNB2CDK1CCNB1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052880-A1 | PYRIDINE DERIVATIVES AS JNK INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | WO | disclosed |