Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562061 | 0.90 | L3MBTL1 (0.61) | KDM4EALOX5LMNAMAPTABCB1 | |
| SCHEMBL11840409 | 0.86 | ALOX5 (0.59) | KDM4EALOX5LMNAMAPTABCB1 | |
| SCHEMBL13752163 | 0.84 | KDM4E (0.60) | KDM4ELMNAMAPTABCB1TDP1 | |
| SCHEMBL6565776 | 0.84 | L3MBTL1 (0.70) | ALOX5MAPTABCB1TDP1ALDH1A1 | |
| SCHEMBL28468685 | 0.83 | GAA (0.63) | KDM4ELMNAABCB1TDP1ALOX15 | |
| SCHEMBL17085323 | 0.83 | KDM4E (0.54) | KDM4ELMNAMAPTABCB1TDP1 | |
| SCHEMBL13401380 | 0.82 | KDM4E (0.59) | KDM4ELMNAABCB1TDP1ALOX15 | |
| SCHEMBL11838953 | 0.82 | LMNA (0.52) | KDM4EALOX5LMNAMAPTABCB1 | |
| SCHEMBL6565628 | 0.81 | PPARA (0.72) | KDM4EALOX5MAPTABCB1ALOX15 | |
| SCHEMBL6563326 | 0.81 | ALOX5 (0.61) | KDM4EALOX5LMNATDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004054988-A1 | ARYLTHIOETHERPYRIMIDINE AND ARYLOXYETHERPYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USES | ACTIVE PASS PHARMACEUTICALS, INC. (CA) | 2004-07-01 | — | — | WO | disclosed |
| EP-0073328-A1 | Novel pyrimidine and s. triazine derivatives with antilipidemic activity | LPB Istituto Farmaceutico s.p.a. (IT) | 1983-03-09 | — | — | EP | disclosed |
| US-3940394-A | ANTILIPEMIC | SANTILLI ARTHUR A | 1976-02-24 | — | — | US | disclosed |