Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | USP1 | O94782 | 1/20 | 0.43 |
| ▸ | USP8 | P40818 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696673 | 0.88 | ALDH1A1 (0.58) | ALDH1A1HPGDMAPK1TSHRNPSR1 | |
| SCHEMBL7694684 | 0.80 | TP53 (0.65) | ALDH1A1HPGDPOLBTSHRHSD17B10 | |
| SCHEMBL7702036 | 0.80 | MAPT (0.62) | ALDH1A1HPGDMAPK1TSHRNPSR1 | |
| SCHEMBL7697083 | 0.78 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPK1TSHRNPSR1 | |
| SCHEMBL7539415 | 0.78 | KMT2A (0.67) | ALDH1A1HPGDPOLBPKMMAPK1 | |
| SCHEMBL7663107 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HPGDMAPK1TSHRNPSR1 | |
| SCHEMBL7701107 | 0.72 | C1R (0.46) | ALDH1A1HPGDMAPK1TSHRNPSR1 | |
| SCHEMBL7700611 | 0.71 | MAPT (0.60) | ALDH1A1HPGDMAPK1TSHRNPSR1 | |
| SCHEMBL7694580 | 0.71 | MEN1 (0.52) | ALDH1A1HPGDPOLBMAPK1TSHR | |
| SCHEMBL7702622 | 0.70 | ALDH1A1 (0.59) | ALDH1A1HPGDMAPK1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737426-B1 | SUCH AS (4-PHENYLSULFONYL-2-PYRIDIN-3-YL-OXAZOL-5-YL)-METHYLAMINE; ANTICONVULSANTS, ANTIINFLAMMATORIES, NEURO-PROTECTANTS, CEREBROPROTECTANTS, NOOTROPICS | MERCK PATENT GMBH (DE) | 2004-05-18 | — | — | US | disclosed |
| EP-1233963-A2 | NOVEL SULFONYL OXAZOLE AMINES | MERCK PATENT GmbH (DE) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001038316-A2 | SULFONYL OXAZOLE AMINES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | MERCK PATENT GMBH (DE) | 2001-05-31 | — | — | WO | disclosed |