Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646398 | 0.82 | AURKA (0.56) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL6825023 | 0.78 | KDM4E (1.00) | KDM4EPOLBALDH1A1MAPTMAPK1 | |
| SCHEMBL6925049 | 0.78 | KDM4E (0.52) | KDM4EALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL6826428 | 0.76 | KDM4E (0.68) | KDM4EPOLBALDH1A1MAPTMAPK1 | |
| SCHEMBL17396514 | 0.75 | KDM4E (0.72) | KDM4EPOLBALDH1A1MAPTMAPK1 | |
| SCHEMBL31219113 | 0.75 | KDM4E (0.72) | KDM4EPOLBALDH1A1MAPTMAPK1 | |
| SCHEMBL28063129 | 0.74 | KIF11 (0.70) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL29816201 | 0.74 | AURKA (0.56) | KDM4EPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3116699 | 0.74 | AURKA (0.56) | KDM4EPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL29894777 | 0.74 | CSNK2A1 (0.51) | KDM4EALDH1A1MAPTMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111052-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE (MDR) | XENOVA LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |