Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 4/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826816 | 0.79 | KDM4E (0.58) | KDM4EALDH1A1HPGDHSD17B10DYRK1A | |
| SCHEMBL6828575 | 0.78 | KDM4E (0.63) | KDM4EALDH1A1HPGDHSD17B10DYRK1A | |
| SCHEMBL31322401 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL263292 | 0.76 | SLC2A1 (0.71) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL29698253 | 0.76 | SLC2A1 (0.71) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL28063129 | 0.74 | KIF11 (0.70) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL31618251 | 0.74 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL17396507 | 0.74 | RXFP1 (0.55) | KDM4EALDH1A1HPGDDYRK1AMEN1 | |
| SCHEMBL31067306 | 0.73 | PARP1 (0.56) | KDM4EALDH1A1HSD17B10DYRK1ARAB9A | |
| SCHEMBL265032 | 0.73 | PARP1 (0.56) | KDM4EALDH1A1HSD17B10DYRK1ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111052-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE (MDR) | XENOVA LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |