Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828379 | 0.95 | ALK (0.49) | TRPV4ALKTNIKKITFLT3 | |
| SCHEMBL6828984 | 0.93 | ALK (0.47) | TRPV4SMN1; SMN2HPGDKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL6828860 | 0.85 | ALDH1A1 (0.47) | TRPV4SMN1; SMN2HPGDKMT2AMAPT | |
| SCHEMBL6830337 | 0.83 | ADORA2A (0.50) | SMN1; SMN2KMT2AADORA2AADORA1HTR2C | |
| SCHEMBL6826020 | 0.83 | NPC1 (0.48) | SMN1; SMN2HPGDKMT2AADORA2AADORA1 | |
| SCHEMBL6828729 | 0.83 | ADORA1 (0.57) | SMN1; SMN2KMT2AMAPTADORA2AADORA1 | |
| SCHEMBL6825903 | 0.82 | HPGD (0.47) | TRPV4SMN1; SMN2HPGDKMT2AMAPT | |
| SCHEMBL6828434 | 0.81 | HDAC1 (0.44) | SMN1; SMN2KMT2AMAPTADORA2AADORA1 | |
| SCHEMBL6828357 | 0.81 | ADORA2A (0.51) | KMT2AMAPTADORA2AADORA1ADORA3 | |
| Hydrochloric Acid SCHEMBL6829009 | 0.81 | HPGD (0.43) | TRPV4SMN1; SMN2HPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |