Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506620 | 0.99 | KDM4E (0.52) | KDM4EALDH1A1LMNAHSD17B10NPC1 | |
| SCHEMBL8268180 | 0.86 | KDM4E (0.67) | KDM4EALDH1A1LMNAHSD17B10NPC1 | |
| SCHEMBL14616345 | 0.84 | ALDH1A1 (0.58) | KDM4EALDH1A1LMNAHSD17B10NPC1 | |
| SCHEMBL5884114 | 0.81 | HPGD (0.65) | KDM4EALDH1A1LMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL6507988 | 0.79 | CTNNB1 (0.47) | KDM4EALDH1A1CTNNB1SMN1; SMN2PIN1 | |
| SCHEMBL9530643 | 0.78 | KDM4E (0.62) | KDM4ELMNANPC1SMN1; SMN2 | |
| SCHEMBL6139297 | 0.76 | LMNA (0.56) | KDM4EALDH1A1LMNAHSD17B10NPC1 | |
| SCHEMBL11632515 | 0.76 | LMNA (0.64) | KDM4ELMNASMN1; SMN2NOD1KMT2A | |
| SCHEMBL11268441 | 0.76 | POLB (0.65) | KDM4EALDH1A1LMNAHSD17B10NPC1 | |
| SCHEMBL3337960 | 0.76 | TNF (0.55) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108723-A1 | 4,5-DIHYDRO-IMIDAZO[4,5,1-II]QUINOLIN-6-ONES AS PARP INHIBITORS | ALTANA PHARMA AG (DE) | 2004-12-16 | — | — | WO | disclosed |