Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.57 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9422768 | 0.86 | KDM4E (0.67) | KDM4EGAAHTTSMN1; SMN2LMNA | |
| SCHEMBL668252 | 0.82 | LMNA (0.66) | KDM4EGAAHTTSMN1; SMN2LMNA | |
| SCHEMBL31485758 | 0.81 | GAA (0.68) | KDM4EGAAHTTSMN1; SMN2LMNA | |
| SCHEMBL16772661 | 0.80 | HDAC6 (0.64) | GAASMN1; SMN2RECQLNPC1 | |
| SCHEMBL14616345 | 0.79 | ALDH1A1 (0.58) | KDM4EHTTSMN1; SMN2LMNATP53 | |
| SCHEMBL6829039 | 0.78 | KDM4E (0.53) | KDM4ESMN1; SMN2LMNANPC1 | |
| SCHEMBL9422759 | 0.78 | APEX1 (0.84) | KDM4EGAAHTTGLAAGTR1 | |
| SCHEMBL2361056 | 0.77 | TP53 (0.69) | GAAHTTSMN1; SMN2LMNATP53 | |
| SCHEMBL540895 | 0.77 | TP53 (0.65) | KDM4EGAAHTTSMN1; SMN2LMNA | |
| SCHEMBL29145233 | 0.77 | CNR2 (0.67) | KDM4EGAAHTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525129-A4 | SUBSTITUTED BENZIMIDAZOLES | — | 1993-03-24 | — | — | EP | disclosed |
| EP-0525129-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-03 | — | — | EP | disclosed |