Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 2/20 | 0.67 |
| ▸ | NT5E | P21589 | 1/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699648 | 0.90 | HINT1 (0.55) | HINT1NT5EADORA2AADORA2BADORA3 | |
| SCHEMBL12673434 | 0.90 | HINT1 (0.55) | HINT1NT5EADORA2AADORA2BADORA3 | |
| SCHEMBL12807374 | 0.90 | HINT1 (0.55) | HINT1NT5EADORA2AADORA2BADORA3 | |
| SCHEMBL2614694 | 0.90 | HINT1 (0.55) | HINT1NT5EADORA2AADORA2BADORA3 | |
| SCHEMBL22002019 | 0.88 | HINT1 (0.56) | HINT1NT5EADORA2AADORA2BADORA3 | |
| SCHEMBL4454099 | 0.88 | ADORA3 (0.80) | HINT1NT5EADORA2AADORA2BADORA3 | |
| SCHEMBL12443734 | 0.88 | ADORA3 (0.80) | HINT1NT5EADORA2AADORA2BADORA3 | |
| SCHEMBL1938203 | 0.88 | ADORA3 (0.80) | HINT1NT5EADORA2AADORA2BADORA3 | |
| SCHEMBL7435435 | 0.86 | AHCY (0.71) | NT5EADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL846034 | 0.85 | ADORA2A (0.58) | HINT1ADORA2AADORA2BADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040214198-A1 | Allele-targeted RNA interference | UNIVERSITY OF MASSACHUSETTS | 2004-10-28 | — | — | US | disclosed |
| WO-2004046324-A2 | ALLELE-TARGETED RNA INTERFERENCE | UNIVERSITY OF MASSACHUSETTS (US) | 2004-06-03 | — | — | WO | disclosed |