Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 6/20 | 0.42 |
| ▸ | TK2 | O00142 | 6/20 | 0.40 |
| ▸ | NT5M | Q9NPB1 | 1/20 | 0.40 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830445 | 1.00 | TK1 (0.42) | TK1TK2NT5MRNASE1 | |
| SCHEMBL18315872 | 0.89 | TK1 (0.41) | TK1TK2NT5MRNASE1 | |
| SCHEMBL6830069 | 0.87 | TK1 (0.38) | TK1TK2RNASE1 | |
| SCHEMBL6827522 | 0.87 | TK1 (0.38) | TK1TK2RNASE1 | |
| SCHEMBL6873193 | 0.83 | TK1 (0.42) | TK1TK2NT5MRNASE1 | |
| SCHEMBL913469 | 0.83 | TK1 (0.40) | TK1TK2NT5M | |
| SCHEMBL25630176 | 0.82 | TK1 (0.41) | TK1TK2NT5MRNASE1 | |
| SCHEMBL8932071 | 0.81 | TOP2A (0.40) | TK1TK2 | |
| SCHEMBL8931965 | 0.81 | TOP2A (0.40) | TK1TK2 | |
| SCHEMBL25401639 | 0.81 | RNASE1 (0.43) | TK1TK2NT5MRNASE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743902-B1 | FOR USE IN ANTISENSE THERAPY FOR ENHANCING NUCLEASE RESISTANCE AND CELLULAR UPTAKE | VALEANT PHARMACEUTICALS INTERNATIONAL | 2004-06-01 | — | — | US | disclosed |
| US-6191266-B1 | MODIFIED TO COMPRISE SUBSTITUTIONS AT POSITIONS C1', C3', C4' OR C5' OF THE SUGAR MOIETY OF THE NUCLEOSIDE, INCLUDING AN OPTIONAL 3' PHOSPHOROAMIDITE GROUP; USE IN MAKING NUCLEASE RESISTANT OLIGONUCLEOTIDES FOR ANTISENSE THERAPY | ICN PHARMACEUTICALS, INC. | 2001-02-20 | — | — | US | disclosed |
| US-5712378-A | SUGAR MOLECULE IS SUBSTITUTED WITH HYDROCARBON OR SUBSTITUTED HYDROCARBON GROUPS, ANTISENSE AGENTS | ICN PHARMACEUTICALS (US) | 1998-01-27 | — | — | US | disclosed |