Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 6/20 | 0.40 |
| ▸ | TK2 | O00142 | 10/20 | 0.39 |
| ▸ | NT5M | Q9NPB1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18315872 | 0.91 | TK1 (0.41) | TK1TK2NT5M | |
| SCHEMBL913471 | 0.88 | TK1 (0.36) | TK1TK2NT5M | |
| SCHEMBL6830445 | 0.83 | TK1 (0.42) | TK1TK2NT5M | |
| SCHEMBL6830442 | 0.83 | TK1 (0.42) | TK1TK2NT5M | |
| SCHEMBL18315873 | 0.79 | TK1 (0.39) | TK1TK2NT5M | |
| SCHEMBL6873193 | 0.78 | TK1 (0.42) | TK1TK2NT5M | |
| SCHEMBL25765053 | 0.77 | TK1 (0.42) | TK1TK2 | |
| SCHEMBL6830069 | 0.77 | TK1 (0.38) | TK1TK2 | |
| SCHEMBL6827522 | 0.77 | TK1 (0.38) | TK1TK2 | |
| SCHEMBL23069380 | 0.76 | TK2 (0.40) | TK1TK2NT5M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3159351-A2 | MODIFIED 3'-AZIDO-4'-ETHYNYL-NUCLEOSIDES AS ANTIVIRAL AGENTS | Gilead Pharmasset LLC (US) | 2017-04-26 | — | — | EP | disclosed |
| EP-1937825-B1 | MODIFIED 4'-NUCLEOSIDES AS ANTIVIRAL AGENTS | GILEAD PHARMASSET LLC (US) | 2016-12-21 | — | — | EP | disclosed |
| US-8569478-B2 | Modified 4′-nucleosides as antiviral agents | GILEAD PHARMASSET LLC (US) | 2013-10-29 | — | — | US | disclosed |
| US-20110021454-A1 | MODIFIED 4`-NUCLEOSIDES AS ANTIVIRAL AGENTS | PHARMASSET, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| EP-1937825-A2 | MODIFIED 4'-NUCLEOSIDES AS ANTIVIRAL AGENTS | Pharmasset, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007038507-A2 | MODIFIED 4'-NUCLEOSIDES AS ANTIVIRAL AGENTS | PHARMASSET, INC. (US) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021454-A1 | MODIFIED 4`-NUCLEOSIDES AS ANTIVIRAL AGENTS | MTAP, PNP, SAMHD1 | TK1 93/4885TK2 315/4885NT5M 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.