SCHEMBL6830451

SCHEMBL6830451

O=C(NC(CP(=O)(O)O)C(=O)O)c1nc2ccccc2[nH]1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIN1 Q13526 6/20 0.49
FAAH O00519 5/20 0.48
SMYD3 Q9H7B4 2/20 0.46
PADI4 Q9UM07 1/20 0.46
PADI2 Q9Y2J8 1/20 0.46
DAGLA Q9Y4D2 1/20 0.45
CNR2 P34972 1/20 0.44
LMNA P02545 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17137470 0.86 PIN1 (0.52) PIN1FAAHSMYD3PADI4PADI2
SCHEMBL17137472 0.86 PIN1 (0.52) PIN1FAAHSMYD3PADI4PADI2
SCHEMBL17154109 0.86 PIN1 (0.52) PIN1FAAHSMYD3PADI4PADI2
SCHEMBL25244025 0.81 PIN1 (0.50) PIN1FAAHSMYD3PADI4PADI2
SCHEMBL29414310 0.81 PIN1 (0.50) PIN1FAAHSMYD3PADI4PADI2
SCHEMBL7347037 0.81 ALDH1A1 (0.56) PIN1FAAHSMYD3PADI4PADI2
SCHEMBL25242832 0.81 PIN1 (0.50) PIN1FAAHSMYD3PADI4PADI2
SCHEMBL29414312 0.81 PIN1 (0.50) PIN1FAAHSMYD3PADI4PADI2
SCHEMBL7347042 0.81 ALDH1A1 (0.56) PIN1FAAHSMYD3PADI4PADI2
SCHEMBL25289343 0.79 P2RX1 (0.52) PIN1FAAHSMYD3PADI4PADI2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1402895-A1 Benzimidazole inhibitors of fructose 1,6-biphosphatase Metabasis Therapeutics, Inc. (US) 2004-03-31 EP disclosed
EP-0970095-B1 NOVEL BENZIMIDAZOLE INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE METABASIS THERAPEUTICS INC (US) 2003-10-29 EP disclosed
US-6399782-B1 ANTIDIABETIC AGENTS METABASIS THERAPEUTICS, INC. 2002-06-04 US disclosed
US-6110903-A INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE AT THE AMP SITE; ADMINISTERING TO TREAT DIABETES AND INHIBIT GLUCONEOGENESIS; 5-FLUORO-7-BROMO-1-ISOBUTYL-2-(2-PHOSPHONO-5-FURANYL) BENZIMIDAZOLE, FOR EXAMPLE SANKYO COMPANY LTD. (JP) 2000-08-29 US disclosed
EP-0970095-A1 NOVEL BENZIMIDAZOLE INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE Metabasis Therapeutics, Inc. (US) 2000-01-12 EP disclosed
WO-1998039343-A9 NOVEL BENZIMIDAZOLE INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE 1999-01-21 WO disclosed
WO-1998039343-A1 NOVEL BENZIMIDAZOLE INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE METABASIS THERAPEUTICS, INC. (US) 1998-09-11 WO disclosed