Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826369 | 0.93 | HTR6 (0.55) | HTR6CYP3A4CYP2D6HTR2AKMT2A | |
| SCHEMBL7068535 | 0.82 | HTR6 (0.54) | HTR6CYP3A4CYP2D6HTR2AKMT2A | |
| SCHEMBL6920527 | 0.73 | HTR6 (0.68) | HTR6CYP3A4CYP2D6HTR2AALDH1A1 | |
| SCHEMBL6830116 | 0.73 | KDM4E (0.51) | HTR6KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL6925689 | 0.73 | SLC2A1 (0.48) | HTR6CYP3A4CYP2D6HTR2AKMT2A | |
| SCHEMBL6925801 | 0.72 | KDM4E (0.48) | HTR6CYP3A4CYP2D6HTR2AKMT2A | |
| SCHEMBL947846 | 0.70 | HTR6 (1.00) | HTR6CYP3A4CYP2D6HTR2A | |
| SCHEMBL29646236 | 0.70 | HTR6 (1.00) | HTR6CYP3A4CYP2D6HTR2A | |
| SCHEMBL6924887 | 0.70 | ALOX5 (0.52) | HTR6CYP3A4CYP2D6KMT2AMEN1 | |
| SCHEMBL6826373 | 0.70 | HRH3 (0.58) | HTR6CYP3A4CYP2D6KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108671-A1 | SUBSTITUTED INDOLES WITH SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-12-16 | — | — | WO | claimed |
| WO-2004108671-A1 | SUBSTITUTED INDOLES WITH SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-12-16 | — | — | WO | disclosed |