Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9376993 | 0.82 | DYRK1A (0.51) | CLK4DYRK1AADORA2AKCNA5CCNB2 | |
| SCHEMBL29808138 | 0.81 | ADORA2A (0.55) | CLK4DYRK1AADORA2ACYP1A2CYP3A4 | |
| SCHEMBL1038650 | 0.81 | ADORA2A (0.55) | CLK4DYRK1AADORA2ACYP1A2CYP3A4 | |
| SCHEMBL29986853 | 0.81 | ADORA2A (0.62) | CLK4DYRK1AADORA2AMAP4K4CYP1A2 | |
| SCHEMBL28872928 | 0.81 | ADORA2A (0.62) | CLK4DYRK1AADORA2AMAP4K4CYP1A2 | |
| SCHEMBL10094648 | 0.78 | DYRK1A (0.62) | CLK4DYRK1AADORA2AKCNA5CCNB2 | |
| SCHEMBL28824499 | 0.78 | CLK4 (0.62) | CLK4DYRK1AKCNA5CCNB2CDK1 | |
| SCHEMBL16047508 | 0.78 | KCNA5 (0.62) | CLK4DYRK1AADORA2AKCNA5SYK | |
| SCHEMBL27290306 | 0.78 | CLK4 (0.53) | CLK4DYRK1AADORA2ACCNB2CDK1 | |
| SCHEMBL18703927 | 0.78 | MAP4K4 (0.52) | CLK4DYRK1AADORA2AKCNA5SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743803-B2 | SUCH AS ALZHEIMER'S DISEASE AND SCHIZOPHRENIA DUE TO HYPOFUNCTION OF GLUTAMIC ACID RECEPTOR; 5-SUBSTITUTED-3-OXADIAZOLYL-1,6-NAPHTHYRIDIN-2(1H)-ONE DERIVATIVES | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2004-06-01 | — | — | US | disclosed |