Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830740 | 0.82 | CLK4 (0.55) | DYRK1ACLK4ADORA2AMAOBKCNA5 | |
| SCHEMBL9375402 | 0.79 | GABRG2 (0.43) | CYP1A2 | |
| SCHEMBL9380466 | 0.78 | DYRK1A (0.51) | DYRK1ACLK4ADORA2AKCNA5TOP1 | |
| SCHEMBL9376329 | 0.74 | MAPT (0.44) | ADORA2ASYK | |
| SCHEMBL10094648 | 0.72 | DYRK1A (0.62) | DYRK1ACLK4ADORA2AKCNA5CCNB2 | |
| SCHEMBL28824499 | 0.72 | CLK4 (0.62) | DYRK1ACLK4KCNA5CCNB2CDK1 | |
| SCHEMBL16047508 | 0.71 | KCNA5 (0.62) | DYRK1ACLK4ADORA2AMAOBKCNA5 | |
| SCHEMBL29986853 | 0.71 | ADORA2A (0.62) | DYRK1ACLK4ADORA2ACYP1A2CYP3A4 | |
| SCHEMBL28872928 | 0.71 | ADORA2A (0.62) | DYRK1ACLK4ADORA2ACYP1A2CYP3A4 | |
| SCHEMBL5368549 | 0.71 | DYRK1A (0.53) | DYRK1ACLK4ADORA2AMAOBKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |