Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | TCF4 | P15884 | 1/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922073 | 0.94 | ALDH1A1 (0.64) | ALDH1A1GAAMAPK1ALOX15MAPT | |
| SCHEMBL6930350 | 0.90 | ALDH1A1 (0.54) | ALDH1A1GAAMAPK1ALOX15MAPT | |
| SCHEMBL6929296 | 0.89 | ALDH1A1 (0.58) | ALDH1A1GAAMAPK1ALOX15MAPT | |
| SCHEMBL6927936 | 0.88 | ALDH1A1 (0.56) | ALDH1A1GAAMAPK1ALOX15MAPT | |
| SCHEMBL6923737 | 0.87 | POLB (0.52) | ALDH1A1GAAMAPK1ALOX15MAPT | |
| SCHEMBL6831392 | 0.85 | ALDH1A1 (0.53) | ALDH1A1GAAMAPK1ALOX15MAPT | |
| SCHEMBL6923759 | 0.84 | POLB (0.57) | ALDH1A1TDP1LMNASMN1; SMN2PKM | |
| SCHEMBL6827973 | 0.84 | PKM (0.61) | ALDH1A1GAATDP1LMNASMN1; SMN2 | |
| SCHEMBL6827768 | 0.84 | ALDH1A1 (0.57) | ALDH1A1GAAMAPK1ALOX15MAPT | |
| SCHEMBL6925728 | 0.84 | ALDH1A1 (0.56) | ALDH1A1GAAMAPK1ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004073619-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | claimed |
| WO-2004073619-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | disclosed |