Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928279 | 0.83 | HTR6 (0.53) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL5553487 | 0.81 | HTR6 (0.83) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| SCHEMBL6826804 | 0.76 | HTR6 (0.61) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| Masupirdine SCHEMBL946320 | 0.72 | HTR6 (1.00) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| Masupirdine SCHEMBL29646265 | 0.72 | HTR6 (1.00) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| Masupirdine SCHEMBL29358531 | 0.72 | HTR6 (1.00) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| Masupirdine SCHEMBL31732770 | 0.71 | HTR6 (0.98) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| Masupirdine SCHEMBL20607627 | 0.71 | HTR6 (0.98) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| SCHEMBL6829699 | 0.70 | HTR6 (0.60) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| SCHEMBL5553534 | 0.70 | HTR6 (1.00) | HTR6CYP3A4CYP2D6ADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108671-A1 | SUBSTITUTED INDOLES WITH SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-12-16 | — | — | WO | disclosed |