Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830157 | 0.87 | HTR6 (0.59) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| SCHEMBL6830687 | 0.83 | HTR6 (0.57) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL6829345 | 0.80 | HTR6 (0.62) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL6924345 | 0.78 | HTR6 (0.59) | HTR6CYP3A4CYP2D6HTR2A | |
| SCHEMBL6829943 | 0.76 | HTR6 (0.46) | HTR6CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6826804 | 0.76 | HTR6 (0.61) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| SCHEMBL7086820 | 0.76 | HTR6 (0.55) | HTR6CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3223044 | 0.75 | HTR6 (1.00) | HTR6CYP3A4CYP2D6ADRA2AADRA2C | |
| SCHEMBL3561901 | 0.75 | ACLY (0.46) | HTR6CHRM1 | |
| SCHEMBL6829316 | 0.74 | HTR6 (0.51) | HTR6CYP3A4CYP2D6ADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108671-A1 | SUBSTITUTED INDOLES WITH SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-12-16 | — | — | WO | claimed |
| WO-2004108671-A1 | SUBSTITUTED INDOLES WITH SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-12-16 | — | — | WO | disclosed |