Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Thiamine Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TKT | P29401 | 10/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiamine Ion SCHEMBL5329756 | 1.00 | HSP90AA1 (0.69) | HSP90AA1TDP1TKTLMNAALDH1A1 | |
| Thiamine Ion SCHEMBL1499694 | 0.94 | HSP90AA1 (0.68) | HSP90AA1TDP1TKTLMNAALDH1A1 | |
| Thiamine Ion SCHEMBL6274353 | 0.94 | HSP90AA1 (0.68) | HSP90AA1TDP1TKTLMNAALDH1A1 | |
| Thiamine Ion SCHEMBL7786248 | 0.93 | HSP90AA1 (0.66) | HSP90AA1TDP1TKTLMNAALDH1A1 | |
| Thiamine Ion SCHEMBL1499696 | 0.92 | HSP90AA1 (0.68) | HSP90AA1TDP1TKTLMNAALDH1A1 | |
| Thiamine Ion SCHEMBL6274356 | 0.92 | HSP90AA1 (0.68) | HSP90AA1TDP1TKTLMNAALDH1A1 | |
| Thiamine Ion SCHEMBL28650146 | 0.92 | HSP90AA1 (0.68) | HSP90AA1TDP1TKTLMNAALDH1A1 | |
| Thiamine Ion SCHEMBL29858574 | 0.92 | HSP90AA1 (0.68) | HSP90AA1TDP1TKTLMNAALDH1A1 | |
| Thiamine Ion SCHEMBL7786252 | 0.92 | HSP90AA1 (0.68) | HSP90AA1TDP1TKTLMNAALDH1A1 | |
| Thiamine Ion SCHEMBL1499697 | 0.92 | HSP90AA1 (0.67) | HSP90AA1TDP1TKTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023157824-A1 | METHOD FOR DETERMINING WHETHER ASC IS INCLUDED AT HIGH PURITY IN ADIPOSE TISSUE-DERIVED CELL POPULATION | 慶應義塾 | 2023-08-24 | — | — | WO | disclosed |
| WO-2023112942-A1 | THERAPY FOR HEPATIC DISORDERS USING ADIPOSE-DERIVED MESENCHYMAL STEM CELL LINE | 慶應義塾 | 2023-06-22 | — | — | WO | disclosed |
| WO-2023085219-A1 | TREATMENT FOR KNEE OSTEOARTHRITIS USING ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELL LINE | 慶應義塾 | 2023-05-19 | — | — | WO | disclosed |
| EP-3339428-B1 | METHOD FOR PRODUCING MESENCHYMAL CELLS WITH PROMOTED C-MPL RECEPTOR EXPRESSION ON CELL SURFACE | ADIPOSEEDS INC (JP) | 2022-05-04 | — | — | EP | disclosed |
| US-20210130785-A1 | MEDIUM FOR INDUCING DIFFERENTIATION OF STEM CELLS INTO MESODERMAL CELLS AND METHOD FOR PRODUCING MESODERMAL CELLS | OSAKA UNIVERSITY (JP) | 2021-05-06 | — | — | US | disclosed |
| US-10704024-B2 | Method for producing mesenchymal cells with promoted c-MPL receptor expression on cell surface | ADIPOSEEDS, INC. (JP) | 2020-07-07 | — | — | US | disclosed |
| US-20190127707-A1 | MEDIUM FOR CULTURING NAIVE PLURIPOTENT STEM CELLS AND METHOD FOR CULTURING PLURIPOTENT STEM CELLS | KYOWA HAKKO BIO CO., LTD. (JP) | 2019-05-02 | — | — | US | disclosed |
| EP-3438248-A1 | NAÏVE PLURIPOTENTIAL STEM CELL CULTURING MEDIUM AND PLURIPOTENTIAL STEM CELL CULTURING METHOD | KYOWA HAKKO BIO CO., LTD. (JP) | 2019-02-06 | — | — | EP | disclosed |
| US-10113147-B2 | Method for producing megakaryocytes, platelets and/or thrombopoietin using mesenchymal cells | ADIPOSEEDS, INC. (JP) | 2018-10-30 | — | — | US | disclosed |
| US-20180245046-A1 | METHOD FOR PRODUCING MESENCHYMAL CELLS WITH PROMOTED c-MPL RECEPTOR EXPRESSION ON CELL SURFACE | KEIO UNIVERSITY (JP) | 2018-08-30 | — | — | US | disclosed |
| EP-3339428-A1 | METHOD FOR PRODUCING MESENCHYMAL CELLS WITH PROMOTED C-MPL RECEPTOR EXPRESSION ON CELL SURFACE | Adiposeeds, Inc. (JP) | 2018-06-27 | — | — | EP | disclosed |
| US-20180127718-A1 | METHOD FOR PRODUCING MEGAKARYOCYTES, PLATELETS AND/OR THROMBOPOIETIN USING MESENCHYMAL CELLS | ADIPOSEEDS INC (JP) | 2018-05-10 | — | — | US | disclosed |
| US-20160177265-A1 | METHOD FOR PRODUCING MEGAKARYOCYTES, PLATELETS AND/OR THROMBOPOIETIN USING MESENCHYMAL CELLS | KANAGAWA INSTITUTE OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2016-06-23 | — | — | US | disclosed |
| US-20040259955-A1 | New pharmaceutical compositions containing ambroxol and isopropamide iodide | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-12-23 | — | — | US | disclosed |