SCHEMBL6832147

SCHEMBL6832147

COc1ccc(C(O[C@@H](CC#N)[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TK1 P04183 5/20 0.47
TYMS P04818 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9614224 0.91 TK1 (0.49) TK1
SCHEMBL6923517 0.90 TK1 (0.51) TK1TYMS
SCHEMBL6831310 0.88 TK1 (0.47) TK1TYMS
SCHEMBL6832207 0.88 TK1 (0.47) TK1TYMS
SCHEMBL6830123 0.87 TOP2A (0.40) TK1
SCHEMBL23039215 0.86 TK1 (0.51) TK1TYMS
SCHEMBL6830154 0.85 TK1 (0.44) TK1
SCHEMBL21577237 0.84 TK1 (0.48) TK1TYMS
SCHEMBL6830784 0.83 RNASE1 (0.39) TK1
SCHEMBL952342 0.82 TK1 (0.46) TK1TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6743902-B1 FOR USE IN ANTISENSE THERAPY FOR ENHANCING NUCLEASE RESISTANCE AND CELLULAR UPTAKE VALEANT PHARMACEUTICALS INTERNATIONAL 2004-06-01 US disclosed
US-6191266-B1 MODIFIED TO COMPRISE SUBSTITUTIONS AT POSITIONS C1', C3', C4' OR C5' OF THE SUGAR MOIETY OF THE NUCLEOSIDE, INCLUDING AN OPTIONAL 3' PHOSPHOROAMIDITE GROUP; USE IN MAKING NUCLEASE RESISTANT OLIGONUCLEOTIDES FOR ANTISENSE THERAPY ICN PHARMACEUTICALS, INC. 2001-02-20 US disclosed
EP-0789706-A4 SUGAR MODIFIED NUCLEOSIDES AND THEIR USE FOR SYNTHESIS OF OLIGONUCLEOTIDES ICN PHARMACEUTICALS (US) 1999-08-11 EP disclosed
US-5712378-A SUGAR MOLECULE IS SUBSTITUTED WITH HYDROCARBON OR SUBSTITUTED HYDROCARBON GROUPS, ANTISENSE AGENTS ICN PHARMACEUTICALS (US) 1998-01-27 US disclosed
EP-0789706-A1 SUGAR MODIFIED NUCLEOSIDES AND THEIR USE FOR SYNTHESIS OF OLIGONUCLEOTIDES ICN PHARMACEUTICALS (US) 1997-08-20 EP disclosed
WO-1996014329-A1 SUGAR MODIFIED NUCLEOSIDES AND THEIR USE FOR SYNTHESIS OF OLIGONUCLEOTIDES ICN PHARMACEUTICALS (US) 1996-05-17 WO disclosed