Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | BCHE | P06276 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12854771 | 0.81 | MAOA (0.45) | HDAC1ALDH1A1KCNH2TDP1 | |
| SCHEMBL6508504 | 0.80 | DRD4 (0.64) | GAAHDAC1ROCK1 | |
| SCHEMBL11881258 | 0.78 | GAA (0.91) | GAAMAPTBCHEKDM4EALDH1A1 | |
| SCHEMBL3272134 | 0.78 | GAA (0.91) | GAAMAPTBCHEKDM4EALDH1A1 | |
| SCHEMBL23642329 | 0.78 | CD274 (0.48) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7995688 | 0.78 | CYP11B1 (0.38) | HDAC1MEN1KMT2ATDP1 | |
| SCHEMBL9511528 | 0.78 | MC4R (0.45) | HDAC1SIGMAR1 | |
| SCHEMBL6832125 | 0.78 | GAA (0.74) | GAAMAPTBCHEKDM4EALDH1A1 | |
| SCHEMBL4468862 | 0.78 | GAA (0.74) | GAAMAPTBCHEKDM4EALDH1A1 | |
| SCHEMBL27228 | 0.76 | GAA (0.95) | GAAMAPTBCHEKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004096771-A1 | BIARYL COMPOUNDS HAVING ACTIVITY AT THE 5HT5A RECEPTOR | GLAXO GROUP LIMITED (GB) | 2004-11-11 | — | — | WO | disclosed |