Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8473559 | 1.00 | TRPA1 (0.45) | TRPA1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL24565100 | 0.90 | ESR1 (0.44) | TRPA1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL9110068 | 0.83 | TRPA1 (0.48) | TRPA1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL2186255 | 0.82 | TRPA1 (0.42) | TRPA1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL24565031 | 0.82 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL24865127 | 0.79 | ALDH1A1 (0.43) | TRPA1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL1454888 | 0.79 | ALDH1A1 (0.43) | TRPA1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL607718 | 0.78 | TRPA1 (0.44) | TRPA1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL607720 | 0.78 | TRPA1 (0.44) | TRPA1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL4971165 | 0.77 | TAAR1 (0.52) | AOC3SLC6A2SLC6A4CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | disclosed |