Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5962395 | 0.85 | ALDH1A1 (0.55) | ALDH1A1KDM4EHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL1327237 | 0.81 | KMT2A (0.56) | PARP1ALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL1328541 | 0.77 | ALDH1A1 (0.51) | PARP1DDB1CRBNALDH1A1KDM4E | |
| SCHEMBL3429807 | 0.75 | PARP1 (0.53) | PARP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL740927 | 0.74 | HSD11B1 (0.57) | PARP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL10647365 | 0.73 | KDM4E (0.48) | PARP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL5087696 | 0.73 | SMN1; SMN2 (0.61) | PARP1DDB1CRBNALDH1A1SMN1; SMN2 | |
| SCHEMBL11096767 | 0.73 | DDB1 (0.48) | PARP1DDB1CRBNALDH1A1KDM4E | |
| SCHEMBL8538146 | 0.73 | ALDH1A1 (0.39) | ALDH1A1KDM4EHSD17B10HPGDRAB9A | |
| SCHEMBL6752009 | 0.73 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |