Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 3/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
| ▸ | ABAT | P80404 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525897 | 0.83 | TSHR (0.43) | GRIK1GRIK2ALDH1A1TSHR | |
| SCHEMBL4278699 | 0.79 | GRIK1 (0.41) | GRIK1GRIK2ALDH1A1TSHR | |
| SCHEMBL3400931 | 0.77 | EP300 (0.43) | ALDH1A1TSHRHCAR2 | |
| SCHEMBL211093 | 0.76 | ALDH1A1 (0.37) | ALDH1A1TSHRHCAR2 | |
| SCHEMBL27045 | 0.74 | — | — | |
| SCHEMBL1875407 | 0.74 | — | — | |
| SCHEMBL800055 | 0.74 | — | — | |
| SCHEMBL7525735 | 0.74 | GRIK1 (0.44) | GRIK1GRIK2FFAR3 | |
| SCHEMBL7525737 | 0.74 | GRIK1 (0.44) | GRIK1GRIK2FFAR3 | |
| SCHEMBL3870449 | 0.72 | HTT (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040121999-A1 | CRF antagonistic pyrazolo[4,3-b]pyridines | NEUROCRINE BIOSCIENCES, INC. | 2004-06-24 | — | — | US | disclosed |
| US-6613777-B1 | Corticotropin releasing factor (CRF) inhibitors such as 5-methyl-7-(dipropylamino)-2-methyl-3-(2,4-dichlorophenyl) pyrazolo(4,3-b)pyridine, used as antidepressants and anxiolytic agents; drug abuse | CHEN CHEN (US) | 2003-09-02 | — | — | US | disclosed |
| WO-1999045007-A1 | CRF ANTAGONISTIC PYRAZOLO[4,3-B]PYRIDINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121999-A1 | CRF antagonistic pyrazolo[4,3-b]pyridines | CRHR1, CRH, CRHR2 | GRIK1 203/4885GRIK2 277/4885FFAR3 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.