Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.54 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.54 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6835913 | 1.00 | BACE1 (0.55) | BACE1PTGER1PTGER3PTGER2PTGER4 | |
| SCHEMBL30317554 | 0.85 | BACE1 (0.58) | BACE1PTGER1PTGER3PTGER2PTGER4 | |
| SCHEMBL181054 | 0.85 | PTGER3 (0.66) | BACE1PTGER1PTGER3PTGER2PTGER4 | |
| SCHEMBL2433472 | 0.85 | PTGER3 (0.66) | BACE1PTGER1PTGER3PTGER2PTGER4 | |
| Hydrochloric Acid SCHEMBL11527565 | 0.83 | PTGER3 (0.64) | BACE1PTGER1PTGER3PTGER2PTGER4 | |
| SCHEMBL9433685 | 0.82 | PTGER1 (0.41) | BACE1PTGER1PTGER3PTGER2PTGER4 | |
| SCHEMBL9433677 | 0.82 | PTGER1 (0.41) | BACE1PTGER1PTGER3PTGER2PTGER4 | |
| SCHEMBL6907589 | 0.82 | NFKB1 (0.50) | NFKB1CA1CA2CA4HDAC8 | |
| SCHEMBL27642891 | 0.81 | BACE1 (0.55) | BACE1PTGER1PTGER3PTGER2PTGER4 | |
| SCHEMBL3667411 | 0.81 | BACE1 (0.55) | BACE1PTGER1PTGER3PTGER2PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040181062-A1 | Benzimidazole cyclooxygenase-2 inhibitor | PFIZER INC | 2004-09-16 | — | — | US | disclosed |
| US-6713482-B2 | SUCH AS (E)-1-(2-PYRIDYL)-2-STYRYL-1H-BENZIMIDAZOLE; ANTIINFLAMMATORY AND ANALGESIC AGENTS; PROSTAGLANDIN INHIBITORS | PFIZER INC. | 2004-03-30 | — | — | US | disclosed |
| US-20030013886-A1 | Benzimidazole cyclooxygenase-2 inhibitors | OKUMURA YOSHIYUKI (JP) | 2003-01-16 | — | — | US | disclosed |
| EP-0937722-B1 | Benzimidazole derivatives as cyclooxygenase-2 inhibitors | PFIZER (US) | 2002-07-03 | — | — | EP | disclosed |
| US-6310079-B1 | NON-STEROIDAL ANTIINFLAMMATORY AGENTS | PFIZER INC. | 2001-10-30 | — | — | US | disclosed |
| EP-0937722-A1 | Benzimidazole derivatives as cyclooxygenase-2 inhibitors | PFIZER INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| US-4140770-A | Benzoylethers and processes for their production | A. NATTERMANN & CIE. GMBH (DE) | 1979-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013886-A1 | Benzimidazole cyclooxygenase-2 inhibitors | PTGS1, CBR1, CBR3 | BACE1 4333/4885PTGER1 12/4885PTGER3 63/4885 |
| US-20040181062-A1 | Benzimidazole cyclooxygenase-2 inhibitor | PTGS1, CBR1, CBR3 | BACE1 4361/4885PTGER1 11/4885PTGER3 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.