Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.62 |
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 3/20 | 0.50 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752531 | 1.00 | MAOA (0.62) | MAOAMAOBALOX5PTGS1PTGS2 | |
| SCHEMBL31202444 | 1.00 | MAOA (0.62) | MAOAMAOBALOX5PTGS1PTGS2 | |
| SCHEMBL10981903 | 0.86 | CYP1A2 (0.57) | MAOAMAOBMAPTALDH1A1LMNA | |
| SCHEMBL7927174 | 0.86 | CYP1A2 (0.57) | MAOAMAOBMAPTALDH1A1LMNA | |
| SCHEMBL5599099 | 0.85 | CYP1A2 (0.61) | MAOAMAOBALOX5PTGS1PTGS2 | |
| SCHEMBL5599097 | 0.85 | CYP1A2 (0.61) | MAOAMAOBALOX5PTGS1PTGS2 | |
| SCHEMBL79073 | 0.83 | NPSR1 (0.62) | MAOAMAOBALOX5PTGS1PTGS2 | |
| SCHEMBL79074 | 0.83 | NPSR1 (0.62) | MAOAMAOBALOX5PTGS1PTGS2 | |
| SCHEMBL29426419 | 0.83 | NPSR1 (0.62) | MAOAMAOBALOX5PTGS1PTGS2 | |
| SCHEMBL8948080 | 0.83 | TDP1 (0.62) | MAOAMAOBALOX5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102838625-B | Tetrahydropyridothiazole compounds, preparation method thereof, pharmaceutical composition containing same and application thereof | SHANGHAI INST MATERIA MEDICA | 2015-04-15 | — | — | CN | disclosed |
| US-20040181062-A1 | Benzimidazole cyclooxygenase-2 inhibitor | PFIZER INC | 2004-09-16 | — | — | US | disclosed |
| US-6713482-B2 | SUCH AS (E)-1-(2-PYRIDYL)-2-STYRYL-1H-BENZIMIDAZOLE; ANTIINFLAMMATORY AND ANALGESIC AGENTS; PROSTAGLANDIN INHIBITORS | PFIZER INC. | 2004-03-30 | — | — | US | disclosed |
| US-20030013886-A1 | Benzimidazole cyclooxygenase-2 inhibitors | OKUMURA YOSHIYUKI (JP) | 2003-01-16 | — | — | US | disclosed |
| EP-0937722-B1 | Benzimidazole derivatives as cyclooxygenase-2 inhibitors | PFIZER (US) | 2002-07-03 | — | — | EP | disclosed |
| US-6323212-B1 | METHOD FOR REDUCING PAIN, WHICH COMPRISES ADMINISTERING AN EFFECTIVE ANALGESIC AMOUNT OF THE MORPHINAN DERIVATIVE | TORAY INDUSTRIES, INC. (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6310079-B1 | NON-STEROIDAL ANTIINFLAMMATORY AGENTS | PFIZER INC. | 2001-10-30 | — | — | US | disclosed |
| US-6277859-B1 | HIGHLY SELECTIVE KAPPA-OPIOID AGONISTS USEFUL AS ANALGESICS AND DIURETICS WITH REDUCED PHYSIOLOGICAL SIDE EFFECTS | TORAY INDUSTRIES, INC. (JP) | 2001-08-21 | — | — | US | disclosed |
| US-6177438-B1 | ANALGESICS, DIURETICS, ANTITUSSIVE AGENTS | TORAY INDUSTRIES, INC. (JP) | 2001-01-23 | — | — | US | disclosed |
| US-6147084-A | Brain cell protective agent | TORAY INDUSTRIES, INC. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0663401-B1 | MORPHINAN DERIVATIVE AND MEDICINAL USE | TORAY INDUSTRIES (JP) | 2000-06-07 | — | — | EP | disclosed |
| US-5972953-A | MORPHINAN DERIVATIVE; USEFAL AS PREVENTIVE AND THERAPUETIC AGENTS OF ISCHEMIC BRAIN DISORDERS, BRAIN NERVE CELL DISORDERS AND DEMENTIA | TORAY INDUSTRIES, LTD. (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0937722-A1 | Benzimidazole derivatives as cyclooxygenase-2 inhibitors | PFIZER INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0661283-B1 | BRAIN CELL PROTECTIVE | TORAY INDUSTRIES (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0577847-B1 | MORPHINAN DERIVATIVE AND MEDICINAL USE | TORAY INDUSTRIES (JP) | 1998-10-14 | — | — | EP | disclosed |
| EP-0846694-A1 | Morphinan derivative and its pharmaceutical applications | TORAY INDUSTRIES, INC. (JP) | 1998-06-10 | — | — | EP | disclosed |
| EP-0663401-A1 | MORPHINAN DERIVATIVE AND MEDICINAL USE | TORAY INDUSTRIES, INC. (JP) | 1995-07-19 | — | — | EP | disclosed |
| EP-0661283-A1 | BRAIN CELL PROTECTIVE | TORAY INDUSTRIES, INC. (JP) | 1995-07-05 | — | — | EP | disclosed |
| EP-0577847-A1 | MORPHINAN DERIVATIVE AND MEDICINAL USE | TORAY INDUSTRIES, INC. (JP) | 1994-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013886-A1 | Benzimidazole cyclooxygenase-2 inhibitors | PTGS1, CBR1, CBR3 | MAOA 3332/4885MAOB 3180/4885ALOX5 118/4885 |
| US-20040181062-A1 | Benzimidazole cyclooxygenase-2 inhibitor | PTGS1, CBR1, CBR3 | MAOA 3428/4885MAOB 3252/4885ALOX5 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.