SCHEMBL68365

SCHEMBL68365

Cc1ccc([N+](=O)[O-])c(CCl)c1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.60
CYP3A4 P08684 1/20 0.60
ALDH1A1 P00352 1/20 0.56
KAT2B Q92831 3/20 0.44
S1PR4 O95977 1/20 0.42
ACHE P22303 3/20 0.42
GPR35 Q9HC97 1/20 0.41
NPC1 O15118 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MAPT P10636 4/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
KDM4E B2RXH2 1/20 0.41
LMNA P02545 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MAPK1 P28482 1/20 0.40
MEN1 O00255 1/20 0.40
RAB9A P51151 1/20 0.40
KMT2A Q03164 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20362277 0.85 TSHR (0.46) TSHRCYP3A4ALDH1A1S1PR4MAPT
SCHEMBL4034840 0.85 TSHR (0.60) TSHRCYP3A4ALDH1A1KAT2BS1PR4
SCHEMBL7193090 0.85 TSHR (0.64) TSHRCYP3A4ALDH1A1KAT2BACHE
SCHEMBL27599498 0.83 TSHR (0.62) TSHRCYP3A4ALDH1A1KAT2BS1PR4
SCHEMBL6907821 0.81 TSHR (0.60) TSHRCYP3A4ALDH1A1KAT2BACHE
SCHEMBL68019 0.81 TSHR (0.60) TSHRCYP3A4ALDH1A1KAT2BACHE
SCHEMBL29137475 0.81 TSHR (0.60) TSHRCYP3A4ALDH1A1KAT2BS1PR4
SCHEMBL16976285 0.81 TSHR (0.60) TSHRCYP3A4ALDH1A1KAT2BS1PR4
SCHEMBL31672310 0.81 TSHR (0.60) TSHRCYP3A4ALDH1A1KAT2BACHE
SCHEMBL67997 0.81 TSHR (0.60) TSHRCYP3A4ALDH1A1KAT2BS1PR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4400166-A2 METHODS FOR IMPLANTING AND REVERSING STIMULI-RESPONSIVE IMPLANTS Contraline, Inc. (US) 2024-07-17 EP claimed
EP-3565484-B1 COMPOSITIONS FOR IMPLANTING AND REVERSING STIMULI-RESPONSIVE IMPLANTS CONTRALINE INC (US) 2024-04-03 EP claimed
EP-3565484-A1 METHODS FOR IMPLANTING AND REVERSING STIMULI-RESPONSIVE IMPLANTS Contraline, Inc. (US) 2019-11-13 EP claimed
WO-2018129369-A1 METHODS FOR IMPLANTING AND REVERSING STIMULI-RESPONSIVE IMPLANTS Contraline, Inc. (US) 2018-07-12 WO claimed
US-20180185096-A1 METHODS FOR IMPLANTING AND REVERSING STIMULI-RESPONSIVE IMPLANTS Contraline, Inc. 2018-07-05 US claimed
US-12383421-B2 Contraceptive devices Contraline, Inc. (US) 2025-08-12 US disclosed
US-20250214963-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH PFIZER INC. 2025-07-03 US disclosed
CN-115066428-B Boric acid derivatives 首药控股(北京)股份有限公司 2025-06-13 CN disclosed
EP-4400166-A2 METHODS FOR IMPLANTING AND REVERSING STIMULI-RESPONSIVE IMPLANTS Contraline, Inc. (US) 2024-07-17 EP disclosed
US-20240109862-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH PFIZER INC. 2024-04-04 US disclosed
EP-3565484-B1 COMPOSITIONS FOR IMPLANTING AND REVERSING STIMULI-RESPONSIVE IMPLANTS CONTRALINE INC (US) 2024-04-03 EP disclosed
CN-114029091-B Dual ligand catalytic system for ethylene selective trimerization, preparation method and application thereof 浙江智英石化技术有限公司 2024-01-16 CN disclosed
WO-1994027954-A1 NITROBENZYL MUSTARD QUATERNARY SALTS AND THEIR USE AS HYPOXIA-SELECTIVE CYTOTOXIC AGENTS AUCKLAND UNISERVICES LIMITED (NZ) 1994-12-08 WO disclosed
CN-1016175-B Imidazoquinoline antithrombin cardiotonic agents BRISTOL MYERS CO (US) 1992-04-08 CN disclosed
EP-0261503-A1 Heterocyclic amido derivatives of substituted benzoic acids and therapeutic compositions which contain them as active principle VALEAS S.p.A. INDUSTRIA CHIMICA E FARMACEUTICA (IT) 1988-03-30 EP disclosed
US-4668686-A 1,3-DIHYDRO-2H-IMIDAZO/4,5-B/QUINOLINE-2-ONES BRISTOL-MYERS COMPANY (US) 1987-05-26 US disclosed
CN-86102747-A The preparation method of imidazoquinoline antithombogehic cardiotonic agents 1987-02-04 CN disclosed
US-4495101-A Antiinflammatory 5H-tetrazolo (5,1-c)(1,4)benzodiazepine derivatives AMERICAN HOME PRODUCTS CORPORATION (US) 1985-01-22 US disclosed
US-4372956-A CARDIOTONIC AGENTS, VASODILATION SANDOZ LTD. (CH) 1983-02-08 US disclosed
EP-0029559-A2 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them SANDOZ AG (CH) 1981-06-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250214963-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH GPR119, INSR, LYAR TSHR 282/4885CYP3A4 4458/4885ALDH1A1 1427/4885
US-20240109862-A1 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH GPR119, INSR, LYAR TSHR 282/4885CYP3A4 4458/4885ALDH1A1 1427/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.