Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | MEN1 | O00255 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.75 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.75 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.75 |
| ▸ | ATM | Q13315 | 1/20 | 0.75 |
| ▸ | NPC1 | O15118 | 6/20 | 0.72 |
| ▸ | RAB9A | P51151 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 9/20 | 0.55 |
| ▸ | TUBB | P07437 | 9/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 9/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 9/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836889 | 1.00 | KDM4E (0.75) | KDM4EMAPTMEN1KMT2ACACNA1B | |
| SCHEMBL4623517 | 0.87 | MEN1 (0.72) | KDM4EMAPTMEN1KMT2ACACNA1B | |
| SCHEMBL20184766 | 0.87 | MAPT (1.00) | KDM4EMAPTMEN1KMT2ACACNA1B | |
| SCHEMBL20184767 | 0.87 | MAPT (1.00) | KDM4EMAPTMEN1KMT2ACACNA1B | |
| SCHEMBL13508624 | 0.86 | MAPT (0.73) | KDM4EMAPTMEN1KMT2ACACNA1B | |
| SCHEMBL2458503 | 0.84 | RAB9A (1.00) | KDM4EMAPTMEN1KMT2ACACNA1B | |
| SCHEMBL2458502 | 0.84 | RAB9A (1.00) | KDM4EMAPTMEN1KMT2ACACNA1B | |
| SCHEMBL29467927 | 0.81 | NPC1 (0.64) | KDM4EMAPTMEN1KMT2ACACNA1B | |
| SCHEMBL29467917 | 0.81 | NPC1 (0.64) | KDM4EMAPTMEN1KMT2ACACNA1B | |
| SCHEMBL28698968 | 0.81 | NPC1 (0.64) | KDM4EMAPTMEN1KMT2ACACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108947911-B | Benzimidazole compound with anti-hepatitis B virus activity and antibacterial activity and synthesis method and application thereof | 中山大学 | 2022-02-22 | — | — | CN | disclosed |
| CN-108947911-A | A kind of benzimidazoles compound and its synthetic method and application with anti-hepatitis B activity and antibacterial activity | 中山大学 | 2018-12-07 | — | — | CN | disclosed |
| US-20040181062-A1 | Benzimidazole cyclooxygenase-2 inhibitor | PFIZER INC | 2004-09-16 | — | — | US | disclosed |
| US-6713482-B2 | SUCH AS (E)-1-(2-PYRIDYL)-2-STYRYL-1H-BENZIMIDAZOLE; ANTIINFLAMMATORY AND ANALGESIC AGENTS; PROSTAGLANDIN INHIBITORS | PFIZER INC. | 2004-03-30 | — | — | US | disclosed |
| US-20030013886-A1 | Benzimidazole cyclooxygenase-2 inhibitors | OKUMURA YOSHIYUKI (JP) | 2003-01-16 | — | — | US | disclosed |
| EP-0937722-B1 | Benzimidazole derivatives as cyclooxygenase-2 inhibitors | PFIZER (US) | 2002-07-03 | — | — | EP | disclosed |
| US-6310079-B1 | NON-STEROIDAL ANTIINFLAMMATORY AGENTS | PFIZER INC. | 2001-10-30 | — | — | US | disclosed |
| EP-0937722-A1 | Benzimidazole derivatives as cyclooxygenase-2 inhibitors | PFIZER INC. (US) | 1999-08-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013886-A1 | Benzimidazole cyclooxygenase-2 inhibitors | PTGS1, CBR1, CBR3 | KDM4E 1257/4885MAPT 4772/4885MEN1 4840/4885 |
| US-20040181062-A1 | Benzimidazole cyclooxygenase-2 inhibitor | PTGS1, CBR1, CBR3 | KDM4E 1153/4885MAPT 4736/4885MEN1 4821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.