Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9564935 | 0.87 | ACE (0.43) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL744269 | 0.79 | ATM (0.57) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL7316279 | 0.79 | ATM (0.57) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL7346811 | 0.79 | ATM (0.57) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL7407045 | 0.79 | ATM (0.57) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL9439279 | 0.79 | ATM (0.57) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL6836752 | 0.76 | KLK5 (0.47) | ACEHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL23699416 | 0.74 | CYP1A2 (0.49) | ACEHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL12879088 | 0.73 | TP53 (0.48) | ACEHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL1204340 | 0.72 | KLK5 (0.57) | ACEKLK5ATMFNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6753409-B1 | FOR TREATMENT OF MYOCARDIAL INFARCTION, STROKE, PERIPHERAL ARTERIAL DISEASE AND DISSEMINATED INTRAVASCULAR COAGULATION | AVENTIS PHARMACEUTICALS INC. | 2004-06-22 | — | — | US | claimed |