Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836756 | 0.87 | ACE (0.42) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL11400555 | 0.82 | CTSS (0.36) | ACEKLK5CTSSCTSLCTSB | |
| SCHEMBL9564886 | 0.82 | REN (0.42) | ACECTSSCTSLCTSBCTSK | |
| SCHEMBL744269 | 0.80 | ATM (0.57) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL7346811 | 0.80 | ATM (0.57) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL9439279 | 0.80 | ATM (0.57) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL7316279 | 0.80 | ATM (0.57) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL7407045 | 0.80 | ATM (0.57) | ACEKLK5ATMAPPCTSS | |
| SCHEMBL2583010 | 0.79 | TACR1 (0.51) | ACEKLK5ITGA4ITGB7HCRTR1 | |
| SCHEMBL2583014 | 0.79 | TACR1 (0.51) | ACEKLK5ITGA4ITGB7HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0565148-A2 | Intermediates for preparation of H-Arg-X-Y-Z-Tyr-R | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-10-13 | — | — | EP | disclosed |
| EP-0042291-B1 | METHODS AND COMPOSITIONS FOR PREPARATION OF H-ARG-X-Z-Y-TYR-R | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-10 | — | — | EP | disclosed |
| EP-0144103-A2 | Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R | ORTHO PHARMACEUTICAL CORPORATION (US) | 1985-06-12 | — | — | EP | disclosed |
| US-4369137-A | N-Protected pentapeptides useful as intermediates in the preparation of thymopoietin pentapeptide | ORTHO PHARMACEUTICAL CORPORATION (US) | 1983-01-18 | — | — | US | disclosed |
| EP-0042291-A2 | Methods and compositions for preparation of H-Arg-X-Z-Y-Tyr-R | ORTHO PHARMACEUTICAL CORPORATION (US) | 1981-12-23 | — | — | EP | disclosed |
| US-4298523-A | OLIGOPEPTIDES OF ARGININE, LYSINE, VALINE, SARCOSINE, ASPARTIC OR GLUTAMIC ACID, AND TYROSINE | ORTHO PHARMACEUTICAL CORPORATION (US) | 1981-11-03 | — | — | US | disclosed |