Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6837376 | 0.76 | ALDH1A1 (0.43) | ALDH1A1POLBMAPTRORCNLRP3 | |
| SCHEMBL3847139 | 0.72 | ALDH1A1 (0.43) | ALDH1A1POLBSMN1; SMN2NPSR1 | |
| SCHEMBL3847137 | 0.72 | ALDH1A1 (0.43) | ALDH1A1POLBSMN1; SMN2NPSR1 | |
| SCHEMBL13873152 | 0.70 | KMT2A (0.44) | ALDH1A1POLBMAPTGAASMN1; SMN2 | |
| SCHEMBL6837449 | 0.67 | ALDH1A1 (0.47) | ALDH1A1POLBMAPTRORC | |
| SCHEMBL3021786 | 0.65 | KMT2A (0.47) | ALDH1A1POLBMAPTGAASMN1; SMN2 | |
| SCHEMBL393212 | 0.65 | MAPT (0.46) | ALDH1A1MAPTGAASMN1; SMN2NPSR1 | |
| SCHEMBL393211 | 0.65 | MAPT (0.46) | ALDH1A1MAPTGAASMN1; SMN2NPSR1 | |
| SCHEMBL3014458 | 0.63 | AKR1B1 (0.41) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14088341 | 0.63 | ALDH1A1 (0.41) | ALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |