SCHEMBL683738

SCHEMBL683738

O=C(N/N=C/c1cc(Cl)cc(Cl)c1O)c1ccccc1O

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 1/20 0.72
KMT2A Q03164 9/20 0.64
MEN1 O00255 8/20 0.64
KDM4E B2RXH2 6/20 0.64
TDP1 Q9NUW8 3/20 0.64
MAPK1 P28482 3/20 0.64
TP53 P04637 1/20 0.64
CYP3A4 P08684 1/20 0.64
CYP2D6 P10635 1/20 0.64
HPGD P15428 1/20 0.64
HSD17B10 Q99714 1/20 0.64
NPC1 O15118 1/20 0.62
USP2 O75604 1/20 0.62
MCOLN3 Q8TDD5 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
NTRK1 P04629 3/20 0.62
KDM1A O60341 1/20 0.60
MAPT P10636 6/20 0.58
HTT P42858 5/20 0.58
ALOX5 P09917 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1639165 1.00 PIK3CG (0.72) PIK3CGKMT2AMEN1KDM4ETDP1
SCHEMBL1639164 1.00 PIK3CG (0.72) PIK3CGKMT2AMEN1KDM4ETDP1
SCHEMBL685177 0.91 PIK3CG (0.67) PIK3CGKMT2AMEN1KDM4ETDP1
SCHEMBL12766766 0.89 KMT2A (0.63) PIK3CGKMT2AMEN1KDM4ETDP1
SCHEMBL1638434 0.89 KMT2A (0.63) PIK3CGKMT2AMEN1KDM4ETDP1
SCHEMBL1638436 0.89 KMT2A (0.63) PIK3CGKMT2AMEN1KDM4ETDP1
SCHEMBL1638608 0.88 KMT2A (0.65) PIK3CGKMT2AMEN1KDM4ETDP1
SCHEMBL684554 0.88 KMT2A (0.65) PIK3CGKMT2AMEN1KDM4ETDP1
SCHEMBL685013 0.88 PIK3CG (0.66) PIK3CGKMT2AMEN1KDM4ETDP1
SCHEMBL1638610 0.88 KMT2A (0.65) PIK3CGKMT2AMEN1KDM4ETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
WO-2012024494-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 WO disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20110098309-A1 METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS ACUMEN PHARMACEUTICALS, INC. (US) 2011-04-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 PIK3CG 2876/4885KMT2A 1362/4885MEN1 536/4885
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER ALG1, SOD1, DHPS PIK3CG 2827/4885KMT2A 2866/4885MEN1 3435/4885
US-20110098309-A1 METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS APP, APBA1, BACE1 PIK3CG 4847/4885KMT2A 3625/4885MEN1 2974/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.