SCHEMBL6837643

SCHEMBL6837643

FC(F)(F)c1nc2ccccc2c2c1nc(-c1ccc[nH]1)n2CCC1CNC1

nearest known ligand 0.38

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ACP1 P24666 12/20 0.38
TLR7 Q9NYK1 1/20 0.33
SSTR4 P31391 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6838715 0.92 ACP1 (0.37) ACP1TLR7
SCHEMBL6840070 0.91 ACP1 (0.49) ACP1
SCHEMBL6838629 0.87 ACP1 (0.33) ACP1TLR7
SCHEMBL6838651 0.87 SLC6A2 (0.35) ACP1TLR7SSTR4
SCHEMBL6833754 0.84 TLR7 (0.34) ACP1TLR7
SCHEMBL6834043 0.83 ADRB2 (0.37) ACP1
SCHEMBL6840149 0.82 TOP2A (0.38) TLR7
SCHEMBL6838504 0.81 KHK (0.33) ACP1
SCHEMBL6838596 0.81 CCR3 (0.34) ACP1
SCHEMBL7500056 0.81 NPY1R (0.38) ACP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040054182-A1 1h-imidazopyridine derivatives HOKURIKU SEIYAKU CO., LTD. (JP) 2004-03-18 US disclosed
EP-1256582-A1 1H-IMIDAZOPYRIDINE DERIVATIVES HOKURIKU SEIYAKU CO., LTD. (JP) 2002-11-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040054182-A1 1h-imidazopyridine derivatives IL2, IL1A, IL4 ACP1 490/4885TLR7 964/4885SSTR4 963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.