Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 5/20 | 0.59 |
| ▸ | NT5E | P21589 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | PNP | P00491 | 1/20 | 0.51 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115914 | 0.92 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL14143259 | 0.92 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL412371 | 0.92 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL19831524 | 0.92 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL22475009 | 0.89 | HINT1 (0.64) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL14440994 | 0.88 | HPGD (0.63) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL21232923 | 0.87 | HINT1 (0.56) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL1738418 | 0.86 | HPGD (0.64) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL1738417 | 0.86 | HPGD (0.64) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL16317882 | 0.86 | HPGD (0.64) | HINT1NT5EGSK3ARPS6KA3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756496-B1 | SUCH AS TRIETHYLAMMONIUM-5'-DIMETHOXYTRITYL-3'-THYMIDINE-HYDROGEN PHOSPHONONDITHIOATE FOR USE AS ANTIVIRAL AND ANTICANCER AGENTS | ISIS PHARMACEUTICALS, INC. | 2004-06-29 | — | — | US | disclosed |
| US-5565555-A | Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues | GILEAD SCIENCES, INC. (US) | 1996-10-15 | — | — | US | disclosed |
| US-5194599-A | Forming linkages with nuclosides and nucleotides; viricides, anticarcinogenic agents | GILEAD SCIENCES, INC. (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0360609-A2 | Novel hydrogen phosphonodithioate compositions | GILEAD SCIENCES, INC. (US) | 1990-03-28 | — | — | EP | disclosed |