Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.48 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.48 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | GNPAT | O15228 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6840688 | 1.00 | SIRT5 (0.51) | SIRT5FOLH1NAALAD2RIMKLAHPGDS | |
| SCHEMBL30944837 | 0.98 | SIRT5 (0.50) | SIRT5FOLH1NAALAD2RIMKLAHPGDS | |
| SCHEMBL17951006 | 0.93 | SIRT5 (0.60) | SIRT5FOLH1NAALAD2RIMKLAHPGDS | |
| SCHEMBL17951005 | 0.88 | SIRT5 (0.53) | SIRT5FOLH1NAALAD2RIMKLAHPGDS | |
| SCHEMBL6519720 | 0.88 | SIRT5 (0.56) | SIRT5FOLH1NAALAD2RIMKLAHPGDS | |
| SCHEMBL14557465 | 0.88 | FOLH1 (0.52) | FOLH1NAALAD2RIMKLAGNPATKDM4E | |
| SCHEMBL17718255 | 0.88 | FOLH1 (0.52) | FOLH1NAALAD2RIMKLAGNPATKDM4E | |
| SCHEMBL11596384 | 0.86 | NOD2 (0.49) | SIRT5FOLH1NAALAD2RIMKLAHPGDS | |
| SCHEMBL24158322 | 0.86 | SIRT5 (0.43) | SIRT5GNPATKDM4EMAPTTHRB | |
| SCHEMBL29150369 | 0.84 | GNPAT (0.53) | SIRT5FOLH1NAALAD2RIMKLAGNPAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130012430-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-10 | — | — | US | disclosed |
| US-8314141-B2 | Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-20 | — | — | US | disclosed |
| US-20090143312-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-06-04 | — | — | US | disclosed |
| US-7388017-B2 | Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-06-17 | — | — | US | disclosed |
| US-6765096-B1 | ANTIALLERGIC AGENT, IMMUNOSUPPRESSANT | SHIONOGI & CO., LTD. (JP) | 2004-07-20 | — | — | US | disclosed |
| CN-1361766-A | Tricyclic compounds having acyloxymethoxycarbonyl side chain | SHIONOGI PHARMACEUTICAL & CO L (JP) | 2002-07-31 | — | — | CN | disclosed |
| EP-1219606-A1 | TRICYCLIC COMPOUNDS BEARING ACYLOXYMETHOXYCARBONYL PENDANTS | SHIONOGI & CO., LTD. (JP) | 2002-07-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143312-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE | HPN, PRSS1, PRSS3 | SIRT5 2977/4885FOLH1 1607/4885NAALAD2 244/4885 |
| US-20130012430-A1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE | HPN, PRSS1, PRSS3 | SIRT5 2977/4885FOLH1 1607/4885NAALAD2 244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.