Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 17/20 | 0.55 |
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4885974 | 0.98 | KDM4E (0.55) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL6843640 | 0.88 | PARP1 (0.44) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL6841122 | 0.86 | PARP1 (0.61) | DHODHPARP1 | |
| SCHEMBL4260461 | 0.86 | KDM4E (0.57) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL15808131 | 0.84 | KDM4E (0.56) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL6841804 | 0.82 | PKN1 (0.57) | KDM4EPARP1 | |
| SCHEMBL9224298 | 0.82 | KDM4E (0.54) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL7474954 | 0.81 | KDM4E (0.52) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL6948954 | 0.81 | NPC1 (0.55) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL7485575 | 0.80 | CHEK1 (0.52) | KDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034078-A1 | Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase | AGOURON PHARMACEUTICALS, INC. | 2004-02-19 | — | — | US | disclosed |
| WO-2003106430-A1 | BENZIMIDAZOLE INHIBITORS OF POLY(ADP-RIBOSYL) POLYMERASE | PFIZER INC. (US) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034078-A1 | Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase | PARP1, PARP11, PARP2 | KDM4E 2460/4885HPGD 885/4885DHODH 1232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.