Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6840806 | 0.97 | SIGMAR1 (0.59) | SIGMAR1DRD2OPRM1OPRL1OPRK1 | |
| SCHEMBL6841700 | 0.95 | SIGMAR1 (0.56) | SIGMAR1DRD2HTR7HTR2AHTR2C | |
| SCHEMBL6840764 | 0.78 | SIGMAR1 (1.00) | SIGMAR1DRD2OPRM1OPRL1OPRK1 | |
| SCHEMBL6843421 | 0.77 | SIGMAR1 (0.65) | SIGMAR1DRD2OPRM1HTR2AHTR2C | |
| SCHEMBL6841619 | 0.77 | SIGMAR1 (0.69) | SIGMAR1DRD2OPRM1OPRL1OPRK1 | |
| SCHEMBL6843241 | 0.77 | SIGMAR1 (0.69) | SIGMAR1DRD2OPRM1OPRL1OPRK1 | |
| SCHEMBL6836334 | 0.76 | HTR2A (0.42) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6836342 | 0.76 | SIGMAR1 (0.56) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6836327 | 0.75 | KDM4E (0.45) | SIGMAR1DRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6840820 | 0.75 | SIGMAR1 (0.93) | SIGMAR1DRD2OPRM1OPRL1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235808-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2000075116-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2000-12-14 | — | — | WO | claimed |
| US-20040266802-A1 | Tricyclic analgesics | CALVET ALAIN (US) | 2004-12-30 | — | — | US | disclosed |
| EP-1235808-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2000075116-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2000-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266802-A1 | Tricyclic analgesics | OPRM1, OPRL1, OPRD1 | SIGMAR1 11/4885DRD2 134/4885OPRM1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.