SCHEMBL6842345

SCHEMBL6842345

O=c1[nH]nc2c3c(cccc13)OCO2

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.44
MAPT P10636 1/20 0.44
RAB9A P51151 1/20 0.44
PARP1 P09874 11/20 0.39
KMT2A Q03164 3/20 0.39
PIM1 P11309 1/20 0.39
CSNK1D P48730 1/20 0.39
TNKS O95271 1/20 0.37
TNKS2 Q9H2K2 1/20 0.37
PARP2 Q9UGN5 1/20 0.37
PARP3 Q9Y6F1 1/20 0.37
ATM Q13315 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
DAO P14920 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7686519 0.69 PARP1 (0.37) NPC1MAPTRAB9APARP1TNKS
SCHEMBL12955370 0.65 PARP1 (0.59) NPC1MAPTRAB9APARP1KMT2A
SCHEMBL30523874 0.65 ABCG2 (0.57) NPC1MAPTRAB9AKMT2AATM
SCHEMBL855338 0.65 PARP1 (0.59) NPC1MAPTPARP1KMT2APIM1
SCHEMBL30930832 0.65 PARP1 (0.59) NPC1MAPTPARP1KMT2APIM1
SCHEMBL3523436 0.65 MAP2K4 (0.57) NPC1MAPTRAB9APARP1KMT2A
SCHEMBL14336647 0.63 PARP1 (0.56) PARP1PIM1CSNK1DATMNPSR1
SCHEMBL14718951 0.63 PARP1 (0.38) PARP1TNKSTNKS2PARP2PARP3
SCHEMBL14336756 0.62 PARP1 (0.61) PARP1KMT2APIM1CSNK1DATM
SCHEMBL3627982 0.61 MAT2A (0.41) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6765006-B2 ANTAGONISTS OF AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID (AMPA) IONOTROPIC RECEPTORS; NEURODEGENERATIVE, ALZHEIMER'S, AND HUNTINGTON'S DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; SCHIZOPHRENIA, EXCITATORY AMINO ACID DEFICIENCY EURO-CELTIQUE S.A. (LU) 2004-07-20 US disclosed
EP-1066039-A4 SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF COCENSYS INC (US) 2003-02-26 EP disclosed
US-6465472-B1 SUCH AS 1-(2-DIETHYLAMINOETHYL)-6,7-METHYLENEDIOXY-4-(3,4-METHYLENE -DIOXYPHENYL)QUINAZOLIN-2(1H)-ONE; AMPA IONOTROPIC RECEPTOR ANTAGONISTS; ANTICONVULSANTS, COGNITIVE ENHANCERS, PREVENTION OF NEURODEGENERATION EURO-CELTIQUE S.A. (LU) 2002-10-15 US disclosed
EP-1066039-A1 SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF Cocensys, Inc. (US) 2001-01-10 EP disclosed
WO-1999044612-A1 SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF COCENSYS, INC. (US) 1999-09-10 WO disclosed