Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842345 | 0.69 | NPC1 (0.44) | PARP1NPC1RAB9ANPSR1TNKS | |
| SCHEMBL3525845 | 0.68 | MAP2K4 (0.45) | PARP1PDE10APKMALDH1A1RAB9A | |
| SCHEMBL10704493 | 0.67 | CA2 (0.49) | PDE10AKDM4EHPGD | |
| SCHEMBL20240850 | 0.66 | KDM4E (0.46) | PARP1TSHRALDH1A1HSD17B10NPC1 | |
| SCHEMBL30523874 | 0.65 | ABCG2 (0.57) | PKMTSHRABCG2ALDH1A1HSD17B10 | |
| SCHEMBL3523207 | 0.65 | PDE3B (0.58) | PARP1TSHRALDH1A1HSD17B10NPC1 | |
| SCHEMBL31749033 | 0.65 | KDM4E (0.33) | TSHRALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL10569556 | 0.65 | CA2 (0.43) | PARP1PKMTSHRABCG2NPC1 | |
| SCHEMBL3627982 | 0.64 | MAT2A (0.41) | ALDH1A1KDM4EHPGD | |
| SCHEMBL10704431 | 0.64 | KDM4E (0.45) | ALDH1A1HSD17B10NPC1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465472-B1 | SUCH AS 1-(2-DIETHYLAMINOETHYL)-6,7-METHYLENEDIOXY-4-(3,4-METHYLENE -DIOXYPHENYL)QUINAZOLIN-2(1H)-ONE; AMPA IONOTROPIC RECEPTOR ANTAGONISTS; ANTICONVULSANTS, COGNITIVE ENHANCERS, PREVENTION OF NEURODEGENERATION | EURO-CELTIQUE S.A. (LU) | 2002-10-15 | — | — | US | disclosed |
| EP-0138490-B1 | 4-alkyl methylenedioxy-2-1[H]-quinazolinones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-04-27 | — | — | EP | disclosed |
| US-4617392-A | 4-alkyl-5,6-methylenedioxy-2-1[H]-quinazolinones useful as cardiotonic agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-10-14 | — | — | US | disclosed |