Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843414 | 0.90 | NR1H4 (0.55) | ALDH1A1NR1H4MMP13HDAC1EPHX2 | |
| SCHEMBL6842679 | 0.90 | MMP13 (0.62) | RAB9ANR1H4MMP13CYP2C9HPGD | |
| SCHEMBL6842637 | 0.89 | NR1H4 (0.61) | ALDH1A1NR1H4MMP13HDAC1EPHX2 | |
| SCHEMBL6845319 | 0.88 | NR1H4 (0.55) | NR1H4MMP13HDAC1EPHX2PPARG | |
| SCHEMBL6843207 | 0.88 | NR1H4 (0.55) | ALDH1A1NR1H4MMP13HDAC1EPHX2 | |
| SCHEMBL6843326 | 0.88 | NR1H4 (0.55) | NPC1RAB9AALDH1A1SMN1; SMN2NR1H4 | |
| SCHEMBL6843480 | 0.88 | NR1H4 (0.55) | RAB9AALDH1A1SMN1; SMN2NR1H4MMP13 | |
| SCHEMBL6195305 | 0.88 | NPC1 (0.61) | NPC1RAB9AALDH1A1SMN1; SMN2NR1H4 | |
| SCHEMBL6838329 | 0.88 | NR1H4 (0.50) | ALDH1A1SMN1; SMN2NR1H4EPHX2PPARG | |
| SCHEMBL6845408 | 0.87 | NR1H4 (0.51) | ALDH1A1NR1H4MMP13HDAC1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040043983-A1 | Naphthalene derivatives as matrix metalloproteinase inhibitors | LI JIE JACK (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043983-A1 | Naphthalene derivatives as matrix metalloproteinase inhibitors | MMP9, MMP8, MMP13 | NPC1 267/4885RAB9A 976/4885ALDH1A1 1588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.