Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6848520 | 0.93 | POLB (0.41) | USP2PABPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL6848106 | 0.88 | HPGD (0.42) | USP2PABPC1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL4625538 | 0.84 | KDM4E (0.45) | USP2PABPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL6848030 | 0.82 | ALDH1A1 (0.33) | ALDH1A1KDM4E | |
| SCHEMBL6847147 | 0.80 | HPGD (0.47) | SMN1; SMN2LMNAPOLBKMT2AALDH1A1 | |
| Nitric Acid SCHEMBL8345678 | 0.79 | MAPK1 (0.45) | USP2PABPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL7048424 | 0.75 | ALDH1A1 (0.40) | USP2PABPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL6843072 | 0.73 | CYP2A6 (0.32) | SMN1; SMN2ALDH1A1KDM4ESTS | |
| SCHEMBL4626526 | 0.70 | HPGD (0.54) | SMN1; SMN2LMNAPOLBKMT2AALDH1A1 | |
| SCHEMBL6847812 | 0.68 | ALDH1A1 (0.34) | SMN1; SMN2ALDH1A1KDM4ESTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1139990-B1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KGAA (DE) | 2004-05-06 | — | — | EP | claimed |
| EP-1139990-B1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KGAA (DE) | 2004-05-06 | — | — | EP | disclosed |
| EP-1139990-A1 | AGENT FOR DYING KERATIN FIBERS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000038635-A1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2000-07-06 | — | — | WO | disclosed |