Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1071414 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAALDH1A1CYP3A4MEN1 | |
| Metamelfalan SCHEMBL2015275 | 0.83 | CYP3A4 (0.70) | SMN1; SMN2LMNAALDH1A1CYP3A4MEN1 | |
| Metamelfalan SCHEMBL30781236 | 0.83 | CYP3A4 (0.70) | SMN1; SMN2LMNAALDH1A1CYP3A4MEN1 | |
| Metamelfalan SCHEMBL2015272 | 0.83 | CYP3A4 (0.70) | SMN1; SMN2LMNAALDH1A1CYP3A4MEN1 | |
| Metamelfalan SCHEMBL6842568 | 0.83 | CYP3A4 (0.70) | SMN1; SMN2LMNAALDH1A1CYP3A4MEN1 | |
| SCHEMBL6838403 | 0.82 | LMNA (0.47) | SMN1; SMN2LMNAALDH1A1CYP3A4MEN1 | |
| SCHEMBL10653540 | 0.82 | LMNA (0.47) | SMN1; SMN2LMNAALDH1A1CYP3A4MEN1 | |
| SCHEMBL11127008 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAALDH1A1CYP3A4MEN1 | |
| Hydrochloric Acid SCHEMBL11124542 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAALDH1A1CYP3A4MEN1 | |
| SCHEMBL29038261 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAALDH1A1CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6767992-B1 | USED FOR CHEMOTHERAPY AGAINST CANCERS AND IS USED ESPECIALLY FOR MELANOMAS | PTC PHARMA AG (CH) | 2004-07-27 | — | — | US | disclosed |
| EP-1129107-B1 | METHOD FOR PRODUCING L-PROLYL-L-M-SARCOLYSYL-L-P-FLUOROPHENYLALANINE AND DERIVATIVES THEREOF | PTC PHARMA AG (CH) | 2003-12-17 | — | — | EP | disclosed |
| EP-1129107-A1 | METHOD FOR PRODUCING L-PROLYL-L-M-SARCOLYSYL-L-P-FLUOROPHENYLALANINE AND DERIVATIVES THEREOF | PTC Pharma AG (CH) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000031119-A1 | METHOD FOR PRODUCING L-PROLYL-L-M-SARCOLYSYL-L-P-FLUOROPHENYLALANINE AND DERIVATIVES THEREOF | PTC PHARMA AG (CH) | 2000-06-02 | — | — | WO | disclosed |
| EP-0056565-B1 | DERIVATIVES OF DI(-2-CHLOROETHYL) AMINOPHENYL ALANINE WITH ANTITUMOUR ACTIVITY | PROTER S.p.A. (IT) | 1984-12-05 | — | — | EP | disclosed |
| EP-0056565-A1 | Derivatives of di(-2-chloroethyl) aminophenyl alanine with antitumour activity | PROTER S.p.A. (IT) | 1982-07-28 | — | — | EP | disclosed |
| US-4216208-A | N-Acyl derivatives of glucosamines having antitumor chemotherapeutic activity | PROTER S.P.A. (IT) | 1980-08-05 | — | — | US | disclosed |