Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.62 |
| ▸ | HTR2A | P28223 | 6/20 | 0.62 |
| ▸ | HTR7 | P34969 | 10/20 | 0.61 |
| ▸ | HTR1A | P08908 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843577 | 0.80 | HTR7 (0.69) | DRD2HTR2AHTR7HTR1ALMNA | |
| SCHEMBL8134762 | 0.80 | HTR7 (0.72) | DRD2HTR2AHTR7HTR1ALMNA | |
| SCHEMBL6844235 | 0.80 | HTR7 (0.60) | DRD2HTR2AHTR7HTR1ALMNA | |
| SCHEMBL29876367 | 0.79 | HTR7 (0.73) | DRD2HTR2AHTR7HTR1ALMNA | |
| SCHEMBL10834835 | 0.77 | DRD2 (0.70) | DRD2HTR2AHTR7HTR1ADRD4 | |
| SCHEMBL27031071 | 0.77 | HTR7 (0.70) | DRD2HTR2AHTR7HTR1ALMNA | |
| SCHEMBL9778482 | 0.77 | HTR7 (0.70) | DRD2HTR2AHTR7HTR1ALMNA | |
| SCHEMBL6839185 | 0.76 | HTR7 (0.65) | DRD2HTR2AHTR7HTR1ALMNA | |
| SCHEMBL11171863 | 0.76 | DRD2 (0.64) | DRD2HTR2AHTR7HTR1ADRD4 | |
| SCHEMBL8406460 | 0.75 | DRD4 (0.48) | DRD2HTR2AHTR7HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116443-A1 | Dopamine D4 ligands for the treatment of novelty-seeking disorders | PFIZER INC | 2004-06-17 | — | — | US | disclosed |
| EP-1177792-A2 | Dopamine D4 Ligands for the treatment of novelty-seeking disorders | Pfizer Products Inc. (US) | 2002-02-06 | — | — | EP | disclosed |
| US-5883094-A | Benzimidazolone derivatives with central dopaminergic activity | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |