Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.72 |
| ▸ | HPGD | P15428 | 7/20 | 0.72 |
| ▸ | MAPT | P10636 | 6/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HTR2A | P28223 | 4/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | UBE2N | P61088 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6845551 | 0.99 | KDM4E (0.70) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| SCHEMBL6847393 | 0.90 | HTR2A (0.71) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| SCHEMBL6845446 | 0.86 | HTR2A (0.61) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| Hydrochloric Acid SCHEMBL6844018 | 0.85 | HTR2A (0.60) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| SCHEMBL6845501 | 0.81 | HTR2A (0.61) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| SCHEMBL6845506 | 0.81 | HTR2A (0.57) | ALDH1A1HTR2AHTR1ATMEM97HTR2C | |
| SCHEMBL6840053 | 0.80 | HTR2A (0.56) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| Hydrochloric Acid SCHEMBL6839998 | 0.79 | HTR1A (0.56) | ALDH1A1HTR2AHTR1ATMEM97 | |
| Hydrochloric Acid SCHEMBL6844055 | 0.79 | HTR2A (0.55) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| SCHEMBL9274709 | 0.79 | HTR2A (0.62) | ALDH1A1KDM4EHPGDMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040176413-A1 | Serotonin antagonists | AVENTIS PHARMACEUTICALS INC. (US) | 2004-09-09 | — | — | US | disclosed |
| US-20030212141-A1 | Serotonin antagonists | NIEDUZAK THADDEUS R (US) | 2003-11-13 | — | — | US | disclosed |
| US-20030083325-A1 | Serotonin antagonists | BANK ONE, N.A. | 2003-05-01 | — | — | US | disclosed |
| US-20020002174-A1 | Serotonin antagonists | NIEDUZAK THADDEUS R (US) | 2002-01-03 | — | — | US | disclosed |
| EP-0637306-B1 | 4-IMIDOMETHYL-1- [2'-PHENYL-2'-OXOETHYL]- PIPERIDINES AS SEROTONIN 5HT 2-ANTAGONISTS, THEIR PREPARATION AND USE IN THERAPY | MERRELL PHARMA INC (US) | 2001-05-30 | — | — | EP | disclosed |
| EP-0637306-A1 | 4-IMIDOMETHYL-1- 2'PHENYL-2'OXOETHYL-] PIPERIDINES AS SEROTONIN 5HT 2?-ANTAGONISTS, THEIR PREPARATION AND USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1995-02-08 | — | — | EP | disclosed |
| WO-1993022309-A1 | 4-IMIDOMETHYL-1-[2'PHENYL-2'OXOETHYL-] PIPERIDINES AS SEROTONIN 5HT2-ANTAGONISTS, THEIR PREPARATION AND USE IN THERAPY | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176413-A1 | Serotonin antagonists | TPH2, TPH1, HTR1A | ALDH1A1 1501/4885KDM4E 3272/4885HPGD 1012/4885 |
| US-20020002174-A1 | Serotonin antagonists | TPH2, TPH1, HTR1A | ALDH1A1 1501/4885KDM4E 3272/4885HPGD 1012/4885 |
| US-20030083325-A1 | Serotonin antagonists | TPH2, TPH1, HTR1A | ALDH1A1 1501/4885KDM4E 3272/4885HPGD 1012/4885 |
| US-20030212141-A1 | Serotonin antagonists | TPH2, TPH1, HTR1A | ALDH1A1 1501/4885KDM4E 3272/4885HPGD 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.