Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988000 | 1.00 | POLB (0.42) | POLBGAAMAPTBRD4DAO | |
| SCHEMBL7969978 | 0.76 | CTRB1 (0.46) | POLBHCAR2MEN1KMT2A | |
| SCHEMBL7991029 | 0.76 | CTRB1 (0.46) | POLBHCAR2MEN1KMT2A | |
| SCHEMBL7973421 | 0.73 | CYP19A1 (0.39) | POLBGAADAOHCAR2HPGD | |
| SCHEMBL25559842 | 0.71 | KDM4E (0.37) | POLBGAAMAPTBRD4DAO | |
| SCHEMBL6652713 | 0.66 | ALDH1A1 (0.40) | POLBGAAMAPTHPGDTSHR | |
| SCHEMBL8111417 | 0.66 | IDO1 (0.48) | POLBGAAMAPTBRD4KDM4E | |
| SCHEMBL7634543 | 0.65 | POLB (0.41) | POLBGAAMAPTBRD4HPGD | |
| SCHEMBL3437947 | 0.65 | TLR4 (0.40) | POLBGAAMAPTHPGDTSHR | |
| Cyclopentane SCHEMBL27502826 | 0.64 | TLR4 (0.39) | POLBGAAMAPTHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206452-B1 | NOVEL METHOD FOR PREPARING BENZOPERHYDROISOINDOLE COMPOUNDS | AVENTIS PHARMA SA (FR) | 2004-11-03 | — | — | EP | disclosed |
| US-6291679-B1 | REACTING 3-OXO-6-PHENYLCYCLOHEX-1-ENE-1-CARBOXYLATE WITH ENZYME FORMING OPTICAL ISOMER; TREATING WITH AMINE PROTECTED N-TRIALKYLSILYLMETHYL-N-(ALKOXYMETHYL)AMINE TO FORM PHENYLPERHYDROISOINDOLE-3A-CARBOXYLATE DERIVATIVE, CYCLIZATION | RHONE-POULENC RORER S.A. (FR) | 2001-09-18 | — | — | US | disclosed |
| EP-1042329-A1 | NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION, PHARMACEUTICAL, COMPOSITIONS CONTAINING THEM AND USE FOR PREPARING MEDICINES | Aventis Pharma S.A. (FR) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033834-A1 | NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE FOR PREPARING MEDICINES | AVENTIS PHARMA S.A. (FR) | 1999-07-08 | — | — | WO | disclosed |