Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | FER | P16591 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373114 | 0.78 | JAK2 (0.40) | JAK2MKNK1AXLMAP4K4CDK2 | |
| SCHEMBL14514439 | 0.77 | JAK2 (0.39) | JAK2MKNK1AXLMAP4K4CDK2 | |
| SCHEMBL5373142 | 0.75 | JAK2 (0.41) | JAK2MKNK1AXLMAP4K4CDK2 | |
| SCHEMBL4006815 | 0.74 | MAPT (0.46) | JAK2AXLMAP4K4CDK2CLK2 | |
| SCHEMBL5379524 | 0.74 | MKNK1 (0.39) | JAK2MKNK1AXLMAP4K4CDK2 | |
| SCHEMBL8253395 | 0.74 | VCP (0.47) | JAK2MKNK1 | |
| SCHEMBL5373162 | 0.73 | ITK (0.50) | — | |
| SCHEMBL7982776 | 0.73 | KDM4E (0.48) | CDK2FLT3TTKKDM4EALDH1A1 | |
| SCHEMBL5377963 | 0.69 | GRM5 (0.47) | JAK2CHEK2JAK1TTK | |
| SCHEMBL7092069 | 0.67 | PRKAG1 (0.48) | MKNK1CLK2DYRK1ATTKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127536-A1 | Methods for treating an inflammatory condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127536-A1 | Methods for treating an inflammatory condition or inhibiting JNK | MAPK1, MAP3K1, MAPKAPK2 | JAK2 123/4885MKNK1 66/4885AXL 4600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.